Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin (EXEBAT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03359824
Recruitment Status : Completed
First Posted : December 2, 2017
Last Update Posted : December 13, 2017
Information provided by (Responsible Party):
Pirjo Nuutila, Turku University Hospital

November 27, 2017
December 2, 2017
December 13, 2017
September 17, 2013
May 27, 2015   (Final data collection date for primary outcome measure)
Cold-induced glucose uptake in BAT after exercise [ Time Frame: Within one study day ]
Glucose uptake of brown adipose tissue acquired with PET under cold exposure after exercise intervention. PET imaging is used to quantify glucose uptake in tissues
Same as current
Complete list of historical versions of study NCT03359824 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin

This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and during cold stimulation.The investigators hypothesize that BAT glucose uptake is increased after exercise and BAT becomes metabolically more active.

Understanding the mechanisms of BAT activation and the role of exercise in humans is crucial to combat epidemic of obesity and diabetes.

Exercise training has been suggested to activate and recruit human BAT through the activation of sympathetic nervous system and contracting skeletal muscles by the release of myokines such as lactate and irisin that signal WAT to induce expression of beige adipocytes. It has been also suggested that exercise training could enhance the metabolism of already existed functional BAT by increasing uncoupling protein-1 (UCP-1) gene transcription, mitochondrial biogenesis and hyperplasia. This is of clinical relevance because brown fat activation has been found to improve metabolic factors linked to obesity and diabetes.

In this study the investigators use a PET radiotracer 2-[18F] flouro-2-deoxy-D-glucose (FDG) to quantify the glucose uptake in BAT, whie adipose tissue and the muscle.The participants are scanned thrice at fast in this study once at room temperature, second at cold exposure and third after six weeks of exercise at cold exposure. This study will provide an insight about the role of exercise in activation of BAT metabolism.

Not Applicable
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Physical Activity
Other: Exercise
Arm: Exercise: Combination of moderate intensity continuous training, high intensity interval training and endurance training 5 times per week for a total of 6 weeks. Out of 5 sessions three were supervised by trainer and two sessions were performed by subjects on their own.The duration of the exercise was increased progressively. The first two weeks was 30 minutes that increased to 45 minutes in the third and fourth week. It was 60 minutes for the last two weeks.
Intervention: Other: Exercise
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
May 27, 2015
May 27, 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy sedentary volunteer

    1. BMI 20-25 kg/m2
    2. Age: 18-35 years
    3. No chronic diseases

Exclusion Criteria:

  1. BMI < 20 kg/m2 or BMI > 25 kg/m2
  2. Mental disorder or poor compliance
  3. Eating disorder or excessive use of alcohol or tobacco smoking
  4. Any chronic disease
  5. Past dose of radiation
  6. Presence of any ferromagnetic objects that would make MR imaging contraindicated
  7. Physically disability which rule out the physical fitness tests or participation in the exercise training intervention
  8. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
Sexes Eligible for Study: Male
18 Years to 35 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Plan to Share IPD: No
Pirjo Nuutila, Turku University Hospital
Turku University Hospital
Not Provided
Principal Investigator: Pirjo Nuutila, MD, PhD Turku UH
Turku University Hospital
December 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP