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Tart Cherry Juice for Exercise Performance and Recovery

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ClinicalTrials.gov Identifier: NCT03313388
Recruitment Status : Completed
First Posted : October 18, 2017
Last Update Posted : June 28, 2018
Sponsor:
Information provided by (Responsible Party):
Phil Chilibeck, University of Saskatchewan

Tracking Information
First Submitted Date  ICMJE October 13, 2017
First Posted Date  ICMJE October 18, 2017
Last Update Posted Date June 28, 2018
Actual Study Start Date  ICMJE October 1, 2017
Actual Primary Completion Date March 30, 2018   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: October 13, 2017)
Time time performance [ Time Frame: Day 5 of beverage consumption ]
Time to complete 10 km of cycling
Original Primary Outcome Measures  ICMJE Same as current
Change History
Current Secondary Outcome Measures  ICMJE
 (submitted: October 17, 2017)
  • Fat oxidation [ Time Frame: Day 5 of beverage consumption ]
    Fat oxidation determined from gas analysis
  • Carbohydrate oxidation [ Time Frame: Day 5 of beverage consumption ]
    Carbohydrate oxidation determined from gas analysis
  • Blood pressure [ Time Frame: Day 5 of beverage consumption ]
    Blood pressure assessed by continuous blood pressure monitor
  • Muscle pain [ Time Frame: Change from baseline to before, and immediately, 24 hours, and 48 hours after exercise ]
    Muscle pain determined by a visual analog scale (participant marks a scale from 0 to 100 mm. A score of 0 mm is "no pain". A score of 100 mm is maximal pain).
  • Quadriceps strength [ Time Frame: Change from baseline to before, and immediately, 24 hours, and 48 hours after exercise ]
    Knee extensor strength determined by isometric contraction
  • Low frequency fatigue [ Time Frame: Change from baseline to before, immediately, 24 hours, and 48 hours after exercise ]
    Measured by force production at low and high stimulation frequencies as an index of muscle damage
Original Secondary Outcome Measures  ICMJE
 (submitted: October 13, 2017)
  • Fat oxidation [ Time Frame: Day 5 of beverage consumption ]
    Fat oxidation determined from gas analysis
  • Carbohydrate oxidation [ Time Frame: Day 5 of beverage consumption ]
    Carbohydrate oxidation determined from gas analysis
  • Blood pressure [ Time Frame: Day 5 of beverage consumption ]
    Blood pressure assessed by continuous blood pressure monitor
  • Muscle pain [ Time Frame: Change from baseline to before, and immediately, 24 hours, and 48 hours after exercise ]
    Muscle pain determined by a visual analog scale
  • Quadriceps strength [ Time Frame: Change from baseline to before, and immediately, 24 hours, and 48 hours after exercise ]
    Knee extensor strength determined by isometric contraction
  • Low frequency fatigue [ Time Frame: Change from baseline to before, immediately, 24 hours, and 48 hours after exercise ]
    Measured by force production at low and high stimulation frequencies as an index of muscle damage
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Tart Cherry Juice for Exercise Performance and Recovery
Official Title  ICMJE The Effect of Tart Cherry Juice on Fat Metabolism, Exercise Performance, and Recovery
Brief Summary This study evaluates the effects of tart cherry juice consumption on endurance exercise performance, fat metabolism during exercise, blood pressure, and recovery from exercise as assessed by muscle pain, muscle strength and electrical properties of muscle. Comparisons will be made to Gatorade consumption. Participants include those who are moderately active and have experience with cycling.
Detailed Description

Tart cherries are rich in bioactive components (i.e. flavonoids) that have anti-inflammatory and anti-oxidant properties. Inflammation and lipid peroxidation causes damage of skeletal muscle membranes during intense exercise. The damage of muscle increases the amount of time for muscle to recover from intense exercise, and can cause muscle strength to be reduced for days. When tart cherries in a concentrated form (i.e. as juice or powder) are consumed in the days leading up to intense exercise, there is a protective effect against inflammation, and lipid peroxidation . This theoretically prevents damage to the lipid component of muscle fibre membranes and helps to preserve muscle function - when muscle is damaged by intense exercise (i.e. either repetitive aerobic activity or high-force muscle contraction), consumption of cherry juice enhances the rate of muscle strength recovery following exercise compared to when a placebo (i.e. non-cherry) beverage is consumed . Muscle damage may be protected by cherry juice consumption; however, all studies evaluating the protective effect of cherries have assessed muscle damage by measuring muscle proteins in the blood. This rather indirect measure of muscle damage is highly variable and not always an accurate assessment of muscle damage; this may be why some studies indicate a reduction in markers of muscle damage with cherry juice consumption while others do not.

A more direct assessment of muscle damage can be obtained by applying electrical stimulation at different frequencies to a muscle before and after intense exercise and assessing the reduction in force output in response to low-frequency and high-frequency stimulation. After intense exercise, the force output at low frequencies of stimulation is often reduced, while the force output at high frequencies is maintained; a phenomenon termed "low frequency fatigue". When muscle is stimulated to contract (either voluntarily by the nervous system or involuntarily through electrical stimulation) calcium is released inside muscle. This calcium release leads to muscle contraction. When muscle undergoes intense exercise, there is damage to muscle membranes, including membranes inside muscle that are responsible for calcium release. This causes a lower amount of calcium to be released with each muscle contraction. Normally, if high frequencies of electrical stimulation are applied to muscle, a very large amount of calcium is released inside muscle - an amount which is "more than enough" to cause a high amount of muscle contraction and high force output. If muscle fibre membranes responsible for release of calcium are damaged, a lower amount of calcium is released, but because "more than enough" calcium is usually released with high frequency stimulation, the lower amount of calcium released with muscle damage is still enough to cause high force of muscle contraction. The force response to low frequencies of stimulation; however, is dramatically reduced when muscle is damaged - usually only a small amount of calcium is released when low frequencies of stimulation are delivered to muscle. Following muscle damage, the smaller amount of calcium released causes lower force production at low stimulation frequency. Low force production at low stimulation frequencies, with a relatively maintained force production at high stimulation frequencies therefore indicates that muscle damage has occurred. This lower muscle force capability at low frequencies of stimulation has dramatic effects on endurance performance because typical endurance performance relies on repeated low-force muscle contractions, as opposed to the few high-force contractions that might be required in other sports (i.e. short sprinting events or field events such as shot put).

The study we are proposing will use this measurement (i.e. ratio of low frequency force to high frequency force output) as a more direct measure of muscle damage. We predict that if cherry juice is consumed in the days leading up to a bout of muscle-damaging endurance exercise, muscle damage will be lower (as indicated by a faster recovery of low-frequency fatigue following the bout of exercise) than when a comparison-drink (i.e. Gatorade) is consumed.

Study Type  ICMJE Interventional
Study Phase  ICMJE Not Applicable
Study Design  ICMJE Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Other
Condition  ICMJE Muscle Damage
Intervention  ICMJE Dietary Supplement: Drink
Beverage to be consumed
Study Arms  ICMJE
  • Experimental: Tart Cherry Juice
    290 mL per day of Tart Cherry juice for 7 days
    Intervention: Dietary Supplement: Drink
  • Active Comparator: Gatorade
    290 mL per day of Gatorade for 7 days
    Intervention: Dietary Supplement: Drink
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: June 27, 2018)
13
Original Estimated Enrollment  ICMJE
 (submitted: October 13, 2017)
12
Actual Study Completion Date  ICMJE April 30, 2018
Actual Primary Completion Date March 30, 2018   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • experienced cyclist (i.e. bicycle exercise at a vigorous intensity on a regular basis)

Exclusion Criteria:

  • Allergies to cherries
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE Yes
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE Canada
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT03313388
Other Study ID Numbers  ICMJE 16-273
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement  ICMJE
Plan to Share IPD: No
Responsible Party Phil Chilibeck, University of Saskatchewan
Study Sponsor  ICMJE University of Saskatchewan
Collaborators  ICMJE Not Provided
Investigators  ICMJE
Principal Investigator: Philip Chilibeck, PhD University of Saskatchewan
PRS Account University of Saskatchewan
Verification Date June 2018

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP