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Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children

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ClinicalTrials.gov Identifier: NCT03260777
Recruitment Status : Not yet recruiting
First Posted : August 24, 2017
Last Update Posted : August 24, 2017
Sponsor:
Information provided by (Responsible Party):
Aya Mohamed, Assiut University

Tracking Information
First Submitted Date August 21, 2017
First Posted Date August 24, 2017
Last Update Posted Date August 24, 2017
Estimated Study Start Date November 18, 2017
Estimated Primary Completion Date September 1, 2018   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: August 23, 2017)
Sensitivity and specificity of the common trichoscopic findings in diagnosis of clinically difficult cases of focal non-cicatricial alopecia in children. [ Time Frame: 2017-2018 ]
Characteristic trichoscopic findings will be searched for in each case such as (exclamation mark hairs, yellow and black dots) for alopecia areata. Flame hairs, tulip hairs, coiled hairs, hook hairs, v-sign and irregularly broken hairs for trichotillomania.Findings for tinea capitis (comma hairs, zigzag hairs, corkscrew hairs and block hairs).Coiled irregularly broken hairs and hair casts for tractional alopecia.
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children
Official Title Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children
Brief Summary

Alopecia is a common, distressing condition that is sometimes difficult to diagnose and treat.

Losing hair is not usually health threatening; it can scar a young child's vulnerable self-esteem by causing immense psychological and emotional stress, not only to the patient, but also to the concerned parents and siblings; so the cause of hair loss should be diagnosed and treated early to overcome the resulting problems.

Detailed Description

The majority of alopecia in children is presented as patchy alopecia, which is most commonly diagnosed as alopecia areata. However, other causes of patchy alopecia such as tinea capitis, trichotillomania, temporal triangular alopecia (TTA), nevus sebaceous and aplasia cutis congenita (ACC) can be easily missed.

Trichoscopy (hair and scalp dermoscopy) is a non-invasive diagnostic tool that allows the recognition of morphologic structures not visible by the naked eye.

Trichoscopy allows visualization of hair shafts at high magnification and performing measurements, such as hair shaft thickness, without the need of removing hair for diagnostic purposes. It also allows in vivo visualization of the epidermal portion of hair follicles and perifollicular epidermis.

The advantages of trichoscopy in evaluating hair loss in children are numerous, as it is a fast in-office technique , non-invasive, inexpensive, and painless , and therefore it will be accepted by children and their parents.

Tinea capitis and alopecia areata are considered to be the most common causes of hairless patches of the scalp in pediatrics. Tinea capitis especially non-scaly type may have the same clinical appearance of alopecia areata, so trichoscopy has recently become a useful diagnostic tool for alopecia areata and tinea capitis, especially in doubtful cases as lab investigations like fungal culture or biopsy may take several weeks.

Study Type Observational
Study Design Observational Model: Case-Only
Time Perspective: Cross-Sectional
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Probability Sample
Study Population 100 Patients with focal non-cicatricial alopecia will be recruited from the outpatient clinic of Dermatology , Venereology and Andrology department at Assiut University Hospital
Condition Focal Non-cicatricial Alopecia
Intervention Device: Trichoscopy
Trichoscopy (hair and scalp dermoscopy) is a noninvasive diagnostic tool that allows the recognition of morphologic structures not visible by the naked eye Structures which may be visualized by trichoscopy include hair shafts of different types, the number of hairs in one pilosebaceous unit, hair follicle openings (dots), the peri and interfollicular areas and the vasculature.
Study Groups/Cohorts
  • children with Alopecia Areata
    Intervention: Device: Trichoscopy
  • children with tinea capitis
    Intervention: Device: Trichoscopy
  • children with trichotillomania
    Intervention: Device: Trichoscopy
  • children with tractional alopecia
    Intervention: Device: Trichoscopy
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Not yet recruiting
Estimated Enrollment
 (submitted: August 23, 2017)
100
Original Estimated Enrollment Same as current
Estimated Study Completion Date January 1, 2019
Estimated Primary Completion Date September 1, 2018   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

-age from 3-18 years of both sexes with focal non-cicatricial alopecia.(1-5 patches of alopecia)

Exclusion Criteria:

  1. Patients who will not consent.
  2. uncooperative children.
  3. patients with active secondary bacterial infection in the alopecic patch.
  4. patients with any concomitant dermatological diseases.
  5. history of using any topical(1 month) or systemic treatment (3 month) for tinea capitis or alopecia areata prior to the study,
  6. cicatricial alopecia.
Sex/Gender
Sexes Eligible for Study: All
Ages 3 Years to 18 Years   (Child, Adult)
Accepts Healthy Volunteers No
Contacts
Contact: Azza M Abdel-Mageed, Prof. Dr 00201001801039 azzamahfouz@yahoo.com
Contact: Reham M Abdel-Gaber, Lecturer 00201005043777 rehamaher707@yahoo.com
Listed Location Countries Not Provided
Removed Location Countries  
 
Administrative Information
NCT Number NCT03260777
Other Study ID Numbers ROTIDDOFNCAIC
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement Not Provided
Responsible Party Aya Mohamed, Assiut University
Study Sponsor Assiut University
Collaborators Not Provided
Investigators Not Provided
PRS Account Assiut University
Verification Date August 2017