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Idiopathic Pulmonary Fibrosis Job Exposures Study (IPFJES)

This study is currently recruiting participants.
See Contacts and Locations
Verified July 2017 by Imperial College London
Sponsor:
Collaborator:
Wellcome Trust
Information provided by (Responsible Party):
Imperial College London
ClinicalTrials.gov Identifier:
NCT03211507
First received: May 2, 2017
Last updated: July 5, 2017
Last verified: July 2017
May 2, 2017
July 5, 2017
May 1, 2017
October 5, 2019   (Final data collection date for primary outcome measure)
Association between asbestos exposure and IPF [ Time Frame: 2 years ]
estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status
Same as current
No Changes Posted
  • Dose-response relationship between asbestos exposure and IPF [ Time Frame: 2 years ]
    estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status
  • Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio. [ Time Frame: 2 years ]
    MUC5B rs35705950 and asbestos exposure odds ratio.
Same as current
Not Provided
Not Provided
 
Idiopathic Pulmonary Fibrosis Job Exposures Study
Idiopathic Pulmonary Fibrosis Job Exposures Study
A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.
Not Provided
Observational
Observational Model: Case-Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
blood
Probability Sample
Hospital based
  • IPF
  • Idiopathic Pulmonary Fibrosis
  • Other: Computer-assisted telephone interview
    Occupational history
  • Genetic: Genetic analysis
    To include analysis of known susceptibility markers
  • Case
    Males with an incident diagnosis of IPF
    Interventions:
    • Other: Computer-assisted telephone interview
    • Genetic: Genetic analysis
  • Controls
    Males with an incident hospital outpatient attendance who do not have IPF
    Interventions:
    • Other: Computer-assisted telephone interview
    • Genetic: Genetic analysis
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
920
October 5, 2020
October 5, 2019   (Final data collection date for primary outcome measure)

For cases

Inclusion Criteria:

  • New diagnosis of IPF between February 2017 and October 2019

Exclusion Criteria:

  • Unable to give informed consent
  • Ever worked outside of the UK

For controls

Inclusion Criteria:

  • New outpatient department attendee between February 2017 and October 2019

Exclusion Criteria:

  • Unable to give informed consent
  • Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy)
  • Diagnosis of IPF
Sexes Eligible for Study: Male
Child, Adult, Senior
No
Contact: Carl Reynolds +44 (0)207 352 8121 ext 3364 carl.reynolds@imperial.ac.uk
Contact: Paul Cullinan p.cullinan@imperial.ac.uk
United Kingdom
 
 
NCT03211507
16SM3627
Yes
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Plan to Share IPD: No
Imperial College London
Imperial College London
Wellcome Trust
Study Director: Carl Reynolds Imperial College London
Imperial College London
July 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP