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Assessing Dementia Risk in the Community: The Dementia Population Risk Tool (DemPoRT)

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ClinicalTrials.gov Identifier: NCT03155815
Recruitment Status : Completed
First Posted : May 16, 2017
Last Update Posted : February 17, 2020
Sponsor:
Collaborators:
Canadian Institutes of Health Research (CIHR)
Institute for Clinical Evaluative Sciences
Information provided by (Responsible Party):
Ottawa Hospital Research Institute

Tracking Information
First Submitted Date May 11, 2017
First Posted Date May 16, 2017
Last Update Posted Date February 17, 2020
Actual Study Start Date September 2000
Actual Primary Completion Date March 2014   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: May 15, 2017)
Dementia capture in administrative data [ Time Frame: Up to 13 years ]
Identification of incident dementia in administrative data using a validated case ascertainment definition, supplemented by dementia codes captured on home care and long-term care assessments
Original Primary Outcome Measures Same as current
Change History
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Assessing Dementia Risk in the Community: The Dementia Population Risk Tool
Official Title Dementia Population Risk Tool (DemPoRT): A Predictive Algorithm for Assessing Dementia Risk in the Community Setting
Brief Summary The purpose of this study is to develop and validate the Dementia Population Risk Tool (DemPoRT) algorithm to predict dementia incidence in the population setting.
Detailed Description

The burden of disease from dementia is a growing global concern as incidence increases exponentially with age and average life expectancy has been increasing around the world. Planning for an aging population requires reliable projections of future dementia prevalence and resource requirements, however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modeling techniques.

The derivation cohort will consist of elderly Ontario respondents of Canadian Community Health Survey (CCHS) (2001, 2003, 2005, 2007; approximately 19 000 males and 25 000 females). Pre-specified predictors include sociodemographic, general health, behavioral, functional and health condition variables. Incident dementia will be identified through individual linkage of survey respondents to population-level administrative health care databases. Using time of first dementia capture as the primary outcome and death as a competing risk, sex-specific proportional hazards regression models will be estimated. The 2008/2009 CCHS survey be used for validation (approximately 4 600 males and 6 300 females). Overall calibration and discrimination will be assessed as well as calibration within predefined subgroups of importance to clinicians and policy makers.

Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Retrospective
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Probability Sample
Study Population The derivation cohort will be eligible respondents to the combined 2001, 2003, 2005 and 2007 Canadian Community Health Surveys, conducted by Statistics Canada. The validation cohort will consist of respondents to the 2008/2009 survey.
Condition Dementia
Intervention Not Provided
Study Groups/Cohorts
  • Derivation Cohort
    Eligible respondents to the combined 2001, 2003, 2005 and 2007 Canadian Community Health Surveys, conducted by Statistics Canada.
  • Validation Cohort
    Eligible respondents to the 2008/2009 Canadian Community Health Survey.
Publications * Fisher S, Hsu A, Mojaverian N, Taljaard M, Huyer G, Manuel DG, Tanuseputro P. Dementia Population Risk Tool (DemPoRT): study protocol for a predictive algorithm assessing dementia risk in the community. BMJ Open. 2017 Oct 24;7(10):e018018. doi: 10.1136/bmjopen-2017-018018.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: February 13, 2020)
75460
Original Estimated Enrollment
 (submitted: May 15, 2017)
35000
Actual Study Completion Date December 2019
Actual Primary Completion Date March 2014   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Respondents to the Canadian Community Health Surveys

Exclusion Criteria:

  • Less than 55 years of age at survey administration
  • Prior history of dementia
  • Not eligible for Ontario's universal health insurance program
Sex/Gender
Sexes Eligible for Study: All
Ages 55 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Not Provided
Removed Location Countries  
 
Administrative Information
NCT Number NCT03155815
Other Study ID Numbers CIHR FRN 142237
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement
Plan to Share IPD: No
Responsible Party Ottawa Hospital Research Institute
Study Sponsor Ottawa Hospital Research Institute
Collaborators
  • Canadian Institutes of Health Research (CIHR)
  • Institute for Clinical Evaluative Sciences
Investigators
Principal Investigator: Peter Tanuseputro Ottawa Hospital Research Institute
PRS Account Ottawa Hospital Research Institute
Verification Date February 2020