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Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia (THINK)

This study is currently recruiting participants.
Verified November 2017 by Hopital Foch
Sponsor:
ClinicalTrials.gov Identifier:
NCT02948465
First Posted: October 28, 2016
Last Update Posted: November 8, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Hopital Foch
October 26, 2016
October 28, 2016
November 8, 2017
July 2016
July 2018   (Final data collection date for primary outcome measure)
Correlation coefficient between biochemical and histological composition of the thrombus and the sensibility in the in vitro fibrinolysis and the origin of the thrombus. [ Time Frame: 1 day ]
Same as current
Complete list of historical versions of study NCT02948465 on ClinicalTrials.gov Archive Site
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Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia
Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia

Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and thrombectomy). Thrombolysis failure by the administration of rt-PA is frequent, in particular in proximal occlusion. Experimental studies suggest that neutrophils could play an important role in the thrombus development via the organization of a network (NET) within the thrombus. Targeting this network of NET could, in addition to the fibrinolysis, increase the rate of recanalisation and thus improve the neurological prognostic after a cerebral infarct.

The aim of the research is to Study of the biochemical and histological composition of the stemming thrombi of cerebral thrombectomies with in vitro analysis of the sensibility in the thrombolysis induced by rt-PA +/- Desoxyribonuclease I (DNase I).

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Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample
Cerebral infact after wide calibre arterial occlusion
Cerebral Infarct
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
120
November 2018
July 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patient over 18
  • Having a cerebral infarct consecutive to a wide calibre arterial occlusion
  • taken care for mechanical thrombectomy

Exclusion Criteria:

  • Patient benefiting from a legal protective measure
  • Pregnant or breast-feeding woman
  • Opposition of the patient to participate in the study
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact: Arturo CONSOLI, MD +33(0)146251955 a.consoli@hopital-foch.com
Contact: Bertrand LAPERGUE, MD
France
 
 
NCT02948465
2016/37
No
Not Provided
Plan to Share IPD: No
Hopital Foch
Hopital Foch
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Principal Investigator: Arturo CONSOLI, MD Hopital Foch
Study Chair: Bertrand LAPERGUE, MD Hopital Foch
Hopital Foch
November 2017