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Safety, Tolerability, PK of Oral NYX-2925 in Healthy Volunteers

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02834741
Recruitment Status : Completed
First Posted : July 15, 2016
Last Update Posted : April 5, 2017
Sponsor:
Collaborator:
Spaulding Clinical Research LLC
Information provided by (Responsible Party):
Aptinyx

Tracking Information
First Submitted Date  ICMJE July 13, 2016
First Posted Date  ICMJE July 15, 2016
Last Update Posted Date April 5, 2017
Study Start Date  ICMJE July 2016
Actual Primary Completion Date March 2017   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: July 14, 2016)
Number of subjects with adverse events [ Time Frame: Subjects will be followed for up to 30 days post-dose ]
Original Primary Outcome Measures  ICMJE Same as current
Change History Complete list of historical versions of study NCT02834741 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures  ICMJE
 (submitted: March 21, 2017)
  • Cmax of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Tmax of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • AUC of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Half-life of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Clearance of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Volume of distribution of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Renal elimination of NYX-2925 [ Time Frame: 0-4, 4-8, 8-12, 12-16, and 16-24 hours post dose. ]
  • Food effect of NYX-2925 following consumption of a high-fat, high-caloric meal [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • CSF penetration of NYX-2925 in CSF cohort [ Time Frame: 1, 2, 2.5, and 8 hours post-dose ]
Original Secondary Outcome Measures  ICMJE
 (submitted: July 14, 2016)
  • Cmax of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Tmax of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • AUC of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Half-life of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Clearance of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Volume of distribution of NYX-2925 [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • Renal elimination of NYX-2925 [ Time Frame: 0-4, 4-8, 8-12, 12-16, and 16-24 hours post dose. ]
  • Food effect of NYX-2925 following consumption of a high-fat, high-caloric meal [ Time Frame: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours post-dose ]
  • CSF penetration of NYX-2925 in CSF cohort [ Time Frame: 1 and 2.5 hours post-dose ]
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Safety, Tolerability, PK of Oral NYX-2925 in Healthy Volunteers
Official Title  ICMJE A Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled, Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of Daily Oral NYX2925 in Healthy Volunteers
Brief Summary This is a first in human study of NYX-2925. It will evaluate single and multiple ascending doses of NYX-2925 in healthy volunteers.
Detailed Description

This is a first in human study of NYX-2925. This is a randomized, double-blind, sponsor-open, placebo-controlled, single and multiple ascending dose, parallel safety, tolerability, and PK study of oral NYX-2925 in healthy volunteers. The single ascending dose phase will comprise up to five dose groups. There will be up to 3 dose groups in the multiple ascending dose phase. One open-label dose group will be repeated in the multiple ascending dose phase to collect cerebrospinal fluid (CSF) samples, in order to explore central nervous system penetration. One elderly cohort (single dose) will be completed after all single and multiple dose escalation groups have completed. One open-label dose group will be repeated in the single ascending dose phase to collect CSF samples, in order to establish a more complete cerebral spinal fluid pharmacokinetic profile.

The influence of food ("food effect") on the bioavailability and pharmacokinetics of NYX-2925 will be explored in one dose group in the single ascending dose phase.

A data review committee will review safety and tolerability (adverse events and other relevant data), plus preliminary pharmacokinetic data, prior to proceeding to the next higher dose group, cohort, and/or phase of the study, as well as administration of the fed dose in the food effect group.

Stopping rules for individual study participants and dose groups or cohorts are established in order to evaluate the dose escalation scheme, the need to stop or terminate dosing, or to establish the maximum tolerated dose. If a cohort is stopped due to safety or tolerability concerns, the previous cohort may be repeated to determine the highest tolerated dose.

Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 1
Study Design  ICMJE Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Condition  ICMJE Healthy Volunteers
Intervention  ICMJE Drug: NYX-2925
NYX-2925 is a small molecule that acts as an N-methyl-D-aspartate receptor (NMDAR) functional glycine-site partial agonist.
Study Arms  ICMJE
  • Placebo Comparator: SAD Phase

    Up to 36 subjects: 50 - 1200 mg NYX-2925, Up to 12 subjects: placebo

    6 additional subjects will receive a fed dose of NYX-2925, 2 additional subjects will receive a fed dose of placebo (Food Effect Cohort)

    6 additional subjects will receive 1 dose of 50 mg NYX-2925 followed by a lumbar puncture at 1 and 4 (3 subjects) or 2 and 8 (3 subjects) hours post dose

    Intervention: Drug: NYX-2925
  • Placebo Comparator: MAD Phase

    Up to 24 subjects : 150 - 600 mg NYX-2925 daily for 7 days, up to 6 subjects : placebo daily for 7 days

    6 additional subjects will receive 300 mg NYX-2925 daily for 7 days and undergo lumbar puncture on Day 6 in order to have two CSF samples taken (CSF Cohort).

    Intervention: Drug: NYX-2925
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: March 21, 2017)
84
Original Estimated Enrollment  ICMJE
 (submitted: July 14, 2016)
70
Actual Study Completion Date  ICMJE March 2017
Actual Primary Completion Date March 2017   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  1. Male and female subjects.
  2. 18 to 55 years of age, inclusive, at the time of signing the informed consent form (ICF). 55 to 80 years of age for elderly cohort.
  3. Female subjects with a negative serum pregnancy test prior to entry into the study and who are practicing an adequate method of birth control (e.g., oral or parenteral contraceptives, intrauterine device, barrier, abstinence) and who do not plan to become pregnant during the course of the study.
  4. Male subjects and their female sexual partner should use an acceptable method of birth control during the study. Male subjects must agree to use barrier contraception (condom with spermicide), and refrain from sperm donation, from the first dose of study drug until 90 days after the last dose of study drug.
  5. Clinical laboratory values within normal limits or deemed not clinically significant by the investigator and/or the sponsor.
  6. Ability to understand the requirements of the study, provide written informed consent, abide by the study restrictions, and agree to return for the required assessments.
  7. Subject is judged to be in good health as determined by the investigator based on the results of a medical history, physical examination (PE), clinical laboratory profile, and electrocardiogram (ECG) performed during the screening period and confirmed prior to dosing.
  8. Body mass index (BMI) between 18 and 30 kg/m2 (inclusive).
  9. Normal renal and hepatic function, with calculated creatinine clearance ≥ 90 mL/minute (Cockcroft-Gault Formula) at Screening or ≥ 60 mL/minute only in the case of the elderly cohort.

Exclusion Criteria:

  1. Clinically significant alcohol or other substance abuse within the last 24 months, in the opinion of the investigator; or, unable to abstain from alcoholic beverages during the course of the study.
  2. Positive screen for alcohol or drugs of abuse (with the exception of a positive result considered by the investigator to be directly attributable to prescription medication approved for subject use): including benzodiazepines, opiates, cocaine, cannabinoids, and amphetamines.
  3. History of smoking or tobacco use within 30 days of Screening.
  4. Women who are pregnant, breast feeding, or planning to become pregnant during the course of the study.
  5. History of allergy, sensitivity, or intolerance to NMDAR ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone, as well as current use of such agents.
  6. Received an investigational drug or device within 30 days (or 5 half-lives, whichever is longer) of dosing.
  7. Previously assigned to treatment during this study (except those who did not take study medication).
  8. Screening QT interval corrected for heart rate by Fridericia's formula (QTcF) > 450 (males) or 470 (females) millisecond (msec) or an ECG that is not suitable for QT measurements (e.g., poorly defined termination of T-wave in the investigator's opinion).
  9. Type I or Type II diabetes.
  10. History of severe renal or hepatic impairment, in the opinion of the investigator or the sponsor-designated medical monitor.
  11. History of excessive bleeding, blood thinners within 6 months, antibiotics or infection within 3 months (CSF cohort only), lumbar spine abnormality, history of elevated intracranial pressure, normal pressure hydrocephalus or other neurological conditions considered clinically significant by the investigator.
  12. Human immunodeficiency virus infection, hepatitis, or other ongoing infectious disease that the investigator considers clinically significant.
  13. Current evidence of dysplasia or history of malignancy (including lymphoma and leukemia) in the last 5 years, with the exception of successfully treated non-metastatic basal cell or squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix.
  14. History of seizures.
  15. History of gastrointestinal disease or surgery (except simple appendectomy or hernia repair), which can influence the absorption of the study drug.
  16. History of any type of psychosis (including but not limited to bipolar disease or schizophrenia).
  17. Medical history or conditions that, in the opinion of the investigator, would preclude safe study participation, or interfere with study procedures/assessments.
  18. Evidence of an infection at the time of clinic admission, in the opinion of the investigator.
  19. Poor venous access.
  20. Use of prescription or over-the-counter medications, including herbal therapies within 7 days prior to dosing, or during the treatment and follow-up periods. Use of St. John's wort within 14 days prior to dosing, or during the treatment and follow-up periods. Occasional aspirin may be used at the investigator's discretion.
  21. Unable to eat a standardized meal offered by the study center.
  22. Donated or had a loss of blood or plasma within 8 weeks prior to dosing.
  23. Grapefruit juice or Seville oranges within 14 days prior to dosing or during the dosing period.
  24. Heart rate ≤ 45 beats per minutes.
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 55 Years   (Adult)
Accepts Healthy Volunteers  ICMJE Yes
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT02834741
Other Study ID Numbers  ICMJE NYX-2925-1001
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE
Plan to Share IPD: Yes
Responsible Party Aptinyx
Study Sponsor  ICMJE Aptinyx
Collaborators  ICMJE Spaulding Clinical Research LLC
Investigators  ICMJE
Principal Investigator: Carlos Sanabria, MD Spaulding Clinical Research LLC
Study Director: Laurel Sindelar Aptinyx Inc.
PRS Account Aptinyx
Verification Date April 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP