The Use of Transcranial Electrical Stimulation for Hallucinations
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|ClinicalTrials.gov Identifier: NCT02715765|
Recruitment Status : Recruiting
First Posted : March 22, 2016
Last Update Posted : November 27, 2017
|First Submitted Date ICMJE||March 16, 2016|
|First Posted Date ICMJE||March 22, 2016|
|Last Update Posted Date||November 27, 2017|
|Study Start Date ICMJE||July 2016|
|Estimated Primary Completion Date||April 2018 (Final data collection date for primary outcome measure)|
|Current Primary Outcome Measures ICMJE
||Reduction in Total Score of the Auditory Hallucinations Rating Scale [ Time Frame: At 1 week and 1 month post treatment. ]|
|Original Primary Outcome Measures ICMJE||Same as current|
|Change History||Complete list of historical versions of study NCT02715765 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE
||Safety and Tolerability of Treatment Based on the Stimulation Side Effect Questionnaire [ Time Frame: 1 week ]|
|Original Secondary Outcome Measures ICMJE||Same as current|
|Current Other Pre-specified Outcome Measures||Not Provided|
|Original Other Pre-specified Outcome Measures||Not Provided|
|Brief Title ICMJE||The Use of Transcranial Electrical Stimulation for Hallucinations|
|Official Title ICMJE||The Use of Transcranial Electrical Stimulation for Hallucinations|
|Brief Summary||Schizophrenia is a serious mental health disorder that affects approximately 1% of the population. Auditory hallucinations are present in as many as 50-75% of patients with this diagnosis. The hallucinations experienced by patients vary greatly and can severely impact an individual's ability to function on a daily basis. In approximately 25-30% of these patients, medication is an ineffective mechanism for managing these symptoms. These hallucinations are known as medication refractory auditory hallucination (MRAH). For those whose auditory hallucinations do not respond to medication, non-surgical brain stimulation (NBS) has recently shown promise as a therapeutic intervention. Two specific types of NBS, called transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS), seem particularly well suited to treating MRAH. They have yet to be compared to each other in large samples of patients with MRAH. The goal of the study is to investigate whether tRNS and tDCS are effective in the treatment of MRAH and if one is better than the other when compared directly.|
Purpose and Background
Schizophrenia is a serious mental health disorder with a constellation of positive, negative, and cognitive symptoms. Negative symptoms can include characteristics such as affective flattening, avolition, and alogia. Positive symptoms can include delusions, hallucinations, and disorganized speech or behavior. Auditory hallucinations (AH) are a hallmark of schizophrenia. They are reported in as many as 50-75% of patients with this diagnosis. The hallucinations experienced by patients vary greatly and can severely impact an individual's ability to function on a daily basis. In approximately 25-30% of patients diagnosed with schizophrenia, medication is an ineffective mechanism for managing these symptoms. These hallucinations are known as medication refractory auditory hallucinations (MRAH). They are defined as "the persistence of daily hallucinations without remission despite antipsychotic medication at an adequate dosage for at least three months".
For those whose AH do not respond to medication, non-surgical brain stimulation (NBS) has recently shown promise as a therapeutic intervention. Specifically, the use of conductive electrical approaches termed transcranial electrical stimulation (tES). One method of tES that has received renewed interest due to its high portability, safety, and modulatory effects is transcranial direct current stimulation (tDCS). tDCS involves applying a weak electrical current using saline soaked electrode sponges, causing either increases or decreases in cortical excitability, respectively. Research has shown in both healthy subjects and patients (e.g. Alzheimer's disease, Parkinson's disease, stroke, and depression) that tDCS has the potential to modulate synaptic and neurotransmitter-dependent plasticity underlying changes in behavior and learning. Brunelin et al utilized tDCS to successfully reduce MRAH in a population diagnosed with schizophrenia. They were able to reduce AH by approximately 30% in their sample after 5 days of twice-daily treatment and this effect was maintained for approximately three months following treatment. This finding has yet to be replicated in a similar study.
Along with tDCS, other new methods of NBS are being investigated across various disease states. One such study looked at the impact of tES on tinnitus. They tested whether type of tES made a difference in efficacy. They compared tDCS to tRNS. tRNS is very similar to tDCS except that it superimposes a random "white noise" gaussian waveform (from 0.1 hz to 640 hz) on top of the DC current. They found that tRNS induced a larger suppressive effect on tinnitus loudness and tinnitus-related distress when compared to tDCS. While their findings were in tinnitus, there are now multiple scholarly works describing a relationship of tinnitus and AH, possibly as a continuum or dimension underlying a variety of normal and disease states. This relationship suggests strategies found to be efficacious for tinnitus may in fact also be efficacious for AH. Recently, there was a case series showing possible efficacy in AH using tRNS.
The purpose of the study is to examine the efficacy of tES in the treatment of MRAH of schizophrenia. The hypothesis is that tRNS will provide a larger reduction of AH in those with schizophrenia as compared to tDCS and no treatment (i.e. sham). Confirmation of this hypothesis would provide an exciting new option for treatment and may provide an even higher level of efficacy than is seen in tDCS. Further, this study would also provide replication of the work by Brunelin et al. and further support of tES as a compelling tool for the management of severe MRAH.
This study is double-blind, between group, and sham-controlled. Subjects will be randomized to one of three arms (tRNS, tDCS, or sham) and will remain in that arm for the duration of the study. All subjects will complete an enrollment visit, ten treatment visits (2 visits per day), and 1, 3, and 6 month follow-up visits. Given that durability of effect has been suggested in the literature to be less than 6 months, patients will not be followed beyond 6 months. The outcome of this study will be measured by standard auditory hallucination rating scales including the Positive and Negative Symptoms Scale (PANSS), Auditory Hallucinations Rating Scale (AHRS), and psychotic symptom rating scales (PSYRATS). Both the AHRS and PSYRATS are included as outcome measures to ensure generalizability to existing studies on tES (which use the AHRS) along with the broader body of AH research (which use the PSYRATS). The primary efficacy parameter will be the PSYRATS as this has shown the most evidence for accurate representation of AH.
This study will recruit individuals who are receiving outpatient services at the Minneapolis VA Medical Center, the University of Minnesota Department of Psychiatry, or the University of Minnesota Medical Center--Fairview. Patients will be referred by clinical staff from multiple departments including Mental Health, Polytrauma, and Social Work. Referral will be based on a clinical diagnosis of Schizophrenia or Schizoaffective disorder with medication refractory auditory hallucinations as assessed by the patient's clinical provider. Subjects will also have the ability to self-identify to flyers and local newspaper ads. Brunelin et al found a large and significant effect size (d=1.58, p<0.001) which the investigators have used to guide our power analysis. The investigators power analysis was performed for three arms using an alpha of 0.025, a power of 0.8, and a desired effect size of 1.00. This analysis results in a need for approximately 20 subjects per arm.
In order to reduce subject burden, the investigators will obtain a waiver of HIPAA authorization and informed consent for recruitment and screening to allow potential subjects to be pre-screened by chart review and in person or by telephone prior to scheduling potential participants for initial visit. Potential participants will be provided with information about the study and asked a series of questions to determine if they meet basic inclusion/exclusion criteria, such as a history of MRAH. They will be told about the basic aims of the study, and those interested in participating will be scheduled for an initial visit at which time they will complete consent paperwork.
The initiation visit (visit 1) starts with completion of informed consent, HIPAA, and the Modified Dysken Tool to assess capacity to consent. The participant must score 7 / 10 on the Dysken Tool in order to participate in the study. Should the participant score less than 7, s/he will be offered remedial teaching and re-assessment. Should the subject agree via consent and demonstrate capacity to consent, s/he is enrolled into the study. A full baseline evaluation is then performed. This includes assessment via MINI, MUPS, PANSS, AHRS, PSYRATS and Edinburgh Handedness Inventory.
Visits 2 - 10 are exclusively treatment visits. At each visit the participant completes the tES Side Effect Questionnaire (TSEQ) both pre and post treatment. Visits occur twice daily for 5 days. Visits must be spaced at least 2 hours apart. Depending on the arm participants have been randomized into, s/he will receive treatment with either tDCS, tRNS, or sham. Treatment will be provided using the Starstim Neurostimulator (Neuroelectrics, Inc.) This device has been approved for use in research in the United States without an investigational device exemption due to meeting criteria for non-significant risk. The same energetic parameters are used for both tDCS and tRNS (2mA for 20 min) as well as the same electrodes (SPONSTIM-25 25cm2 electrodes). Both tDCS and tRNS are initiated in a ramp-like fashion over 10s from 0mA to 2mA. Once at 2mA, tDCS is held constant for the entire session whereas the tRNS consists of an alternating current of 2mA with a 0mA offset applied at random frequencies over a range of 0.1 to 100 Hz. The sham procedure involves only 40 sec stimulation at 2mA and then drops to 0mA with 15msec pulses every 550msec. Should the participant not be able to tolerate a current of 2mA due to pain or irritation, the current will be decreased down to a minimum of 1.5mA. If 1.5 mA is still not tolerable, the participant will be removed from the study. Electrode placement is based on the international 10-20 electrode placement system. The anode is placed at the midpoint between F3 and FP1, a location corresponding approximately to the left dorsolateral prefrontal cortex, and the cathode placed at the midpoint between T3 and P3, a location corresponding to left temporo-parietal junction. Placement and parameters in tDCS are consistent with Brunelin et al, 2012). Placement and parameters in tRNS are consistent with. Stimulation setup and administration takes approximately 30 minutes.
Visit 11 is run the same as visits 2 - 10 but after completion of the final (10th) stimulation session, the subject will again complete the PANSS, AHRS, and PSYRATS. This visit typically takes 90 minutes.
Visits 12 - 14 are follow-up assessment only visits and occur at 1 month, 3 month, and 6 months post treatment. Participants will not receive stimulation but instead will be assessed via PANSS, AHRS, and PSYRATS.
In the event that a participant misses a session of treatment, the session will be re-scheduled and treatment continued as soon as possible. The deviation from treatment will be noted in the study record.
Informed Consent Process
Consenting will take place in a private office at the Minneapolis VA Health Care System, University of Minnesota 717 Delaware office, the Ambulatory Research Center of the University of Minnesota Department of Psychiatry, or the UMPhysicians MINCEP clinic, depending on patient preference. Only the study staff obtaining consent, the subject, and any family members invited by the subject will be present. The research coordinator or other trained research staff will explain the study to the participants. After explaining the study, the participants will be allowed as much time as needed to review the HIPAA and consenting documents and ask any questions that might arise before making the decision to participate. If necessary, participants can delay participation for up to a week. Subjects will be allowed to review the consent form in private for as long as they need. Subjects will be allowed to ask any and all questions prior to providing consent. Study personnel obtaining consent will emphasize first and foremost that the study is voluntary and will not influence that subject's clinical care through the VA Medical Center, University of Minnesota Medical Center--Fairview, or the University of Minnesota Department of Psychiatry. To ensure comprehension of the information provided in the informed consent forms, participants will be asked to complete the Modified Dysken Tool and answer 7 out of 10 questions correctly.
Indications of Lack of Capacity to Consent
No participant will be under legal commitment at the time of their consent or during their participation in the study.
Data will be analyzed for group by time effects of stimulation method as compared to sham. Tolerability will also be assessed by looking at total side effect score compared to stimulation type. The data will be further analyzed using a clustering technique to understand the impact of symptom cluster and severity on overall treatment response.
Potential Risks and Benefits
This study involves the use of a tES device. With tES, both tDCS and tRNS are considered to be safe brain stimulation techniques that rarely result in adverse events. There is currently no evidence of serious side-effects. Criteria for discontinuation that may rarely occur are sores at the tCS administration site, headaches that impair global functioning, and worsening psychosis. Mild side-effects that typically resolve upon discontinuation tCS include light itching under the electrode at the beginning of administration, headache, fatigue, and nausea. The participant may choose to discontinue stimulation at any time during the session if experiencing discomfort or side effects. No other risks are anticipated. Nonetheless, in order to minimize risks, study staff will be using standards of administration that have been shown to be safe in numerous other studies and across more than 2000 studies using tES; this includes length of administration, magnitude of the current, size of electrode sponges used, and method of applying stimulation. Any unanticipated problems or adverse events will be reported according to MVAHCS standard operating procedure.
Study staff will use private (medical or educational) records during the recruitment process. Therefore, the use of protected health information may be associated with negative feelings about sharing medical/educational history. Participants may experience mild stress and/or discomfort with completing surveys/interview. Participants could also experience temporary feelings of stress or mental fatigue due to the behavioral assessment measures used in the study.
In addition, breach of confidentiality is a potential risk due to the use of sensitive private information. The results of this study may be published or presented but the participant's identity and records will not be revealed unless required by Federal Law. A Federal Law allows the U.S. Food and Drug Administration, Office for Human Research Protections, Government Accountability Office and other Federal agencies, the Research and Development Committee, representatives of USAMRMC, Henry M. Jackson Foundation, and/or the Institutional Review Board (IRB)/Human Studies Subcommittee of the VA Medical Center or University of Minnesota to review records. Because of the need for these inspections, absolute confidentiality cannot be guaranteed. However, every effort would be made to minimize these risks by providing the participant with a unique numerical identifier at the beginning of the study in order to protect their actual identification and maintain complete confidentiality.
It is possible that a participant may have a reduction of symptoms from the tES treatment but there are no anticipated direct or societal benefits to participation in this research project.
A MVAHCS or University of Minnesota staff will act as an independent research monitor for this study. Her/His duties may include discussing the research protocol and recruitment with the investigator and staff, monitoring utilization of the tES device, follow-up with any participants in which an adverse event was reported, and reporting findings to the IRB.
Sores at the tES administration site Headaches that impair global functioning Worsening psychosis
Privacy, Confidentiality, and Information Security
Self-report data will be collected on paper and scanned and stored in a password protected database behind the MVAMC or University of Minnesota firewalls. All personal identifiers will be stored on the consent form and in a master participant list within the database. All other documents will contain the unique participant ID. All paper documents related to this study will be stored in a locked file cabinet within locked research study offices. Access to research data and documents will be restricted to research personnel listed on the study protocol.
All data will be maintained at the MVAHCS and University of Minnesota indefinitely per requisite data retention policies. No data will be destroyed. Information regarding research results will not be shared with study participants.
|Study Type ICMJE||Interventional|
|Study Phase ICMJE||Not Applicable|
|Study Design ICMJE||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Study Arms ICMJE||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Recruiting|
|Estimated Enrollment ICMJE
|Original Estimated Enrollment ICMJE||Same as current|
|Estimated Study Completion Date ICMJE||October 2018|
|Estimated Primary Completion Date||April 2018 (Final data collection date for primary outcome measure)|
|Eligibility Criteria ICMJE||
|Ages ICMJE||18 Years to 64 Years (Adult)|
|Accepts Healthy Volunteers ICMJE||No|
|Listed Location Countries ICMJE||United States|
|Removed Location Countries|
|NCT Number ICMJE||NCT02715765|
|Other Study ID Numbers ICMJE||1512M81581|
|Has Data Monitoring Committee||No|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement ICMJE||
|Responsible Party||University of Minnesota - Clinical and Translational Science Institute|
|Study Sponsor ICMJE||University of Minnesota - Clinical and Translational Science Institute|
|Collaborators ICMJE||Minneapolis Veterans Affairs Medical Center|
|Investigators ICMJE||Not Provided|
|PRS Account||University of Minnesota - Clinical and Translational Science Institute|
|Verification Date||November 2017|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP