Efficacy of Rechallenge With Sunitinib in Metastatic Pancreatic Neuroendocrine Tumor Previously Failed to Sunitinib (RESUNET)

• ClinicalTrials.gov Identifier: NCT02713763
• Recruitment Status: Completed
• First Posted: March 21, 2016
• Last Update Posted: March 4, 2020
• Sponsor: Grupo Espanol de Tumores Neuroendocrinos
• Collaborators: Pfizer; Apices Soluciones S.L.
• Information provided by (Responsible Party): Grupo Espanol de Tumores Neuroendocrinos

Tracking Information

• First Submitted Date: March 16, 2016
• First Posted Date: March 21, 2016
• Last Update Posted Date: March 4, 2020
• Actual Study Start Date: February 14, 2017
• Actual Primary Completion Date: October 23, 2019 (Final data collection date for primary outcome measure)

Current Primary Outcome Measures (submitted: March 18, 2016)

6 months progression free survival [ Time Frame: 6 months ]

Time form start of treatment to progression disease

• Original Primary Outcome Measures: Same as current

Current Secondary Outcome Measures (submitted: February 5, 2019)

• Overall survival [ Time Frame: 2 years ]
  Time form start of treatment to death
• Progression free survival [ Time Frame: 12 months ]
  Time form start of treatment to progression disease
• Response duration [ Time Frame: 12 months ]
  Time from first response to progression disease
• Overall response rate [ Time Frame: 12 months ]
  Complete response + partial response
• Incidence of Adverse Events [ Time Frame: 12 months ]
  Number of adverse events per patient

Original Secondary Outcome Measures (submitted: March 18, 2016)

• Overall survival [ Time Frame: 2 years ]
  Time form start of treatment to death
• Progression free survival [ Time Frame: 12 months ]
  Time form start of treatment to progression disease
• Response duration [ Time Frame: 12 months ]
  Time from first response to progression disease
• Overall response rate [ Time Frame: 12 months ]
  Complete response + partial response
• Safety [ Time Frame: 12 months ]
  Number of adverse events per patient

• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: Efficacy of Rechallenge With Sunitinib in Metastatic Pancreatic Neuroendocrine Tumor Previously Failed to Sunitinib
• Official Title: Phase II Study to Evaluate Efficacy of Rechallenge With Sunitinib in Patients With Metastatic Pancreatic Neuroendocrine Tumor (pNETs) Well Differentiated G1/2 Advanced or Metastatic Who Previously Failed to Sunitinib.

Brief Summary

The therapeutic goals in the management of pancreatic neuroendocrine tumors (pNET) are the control of symptoms and tumor growth control in order to improve patient survival.

In recent years, data from two phase III studies with targeted therapies, sunitinib and everolimus, have broadened the possibilities for treatment of patients with neuroendocrine tumors of the pancreas.

Unfortunately, patients progress and development of new active drugs and evaluating the best treatment approach is decisive.

Given the lack of data comparing the activity of different treatment strategies, final decisions are based on medical experience and consensus of experts. In this context, different questions are still unanswered, as which is the best sequence of treatment and if all patients can benefit from all available drugs.

Neuroendocrine pancreatic tumors are highly vascularized tumors in which cells may be dependent on this pathway for growth throughout the entire history of the tumor and in which inhibition of this pathway is crucial. On the other hand, this aspect has not been endorsed by the population of patients with pNET who have previously failed treatment with sunitinib.

In this scenario the investigators will assess retreatment with sunitinib to evaluate the activity of this drug in the context of therapeutic rescue in patients with metastatic pNET.

• Detailed Description: Not Provided
• Study Type: Interventional
• Study Phase: Phase 2
• Study Design: Allocation: N/A; Intervention Model: Single Group Assignment; Masking: None (Open Label); Primary Purpose: Treatment
• Condition: Pancreatic Neuroendocrine Tumour Metastatic

Intervention

Drug: Sunitinib

Sunitinib 37.5 mg/day

Other Name: Sutent

Study Arms

Experimental: Sunitinib

Sunitinib 37.5 mg/day

Intervention: Drug: Sunitinib

• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Completed
• Actual Enrollment (submitted: October 7, 2019): 11
• Original Estimated Enrollment (submitted: March 18, 2016): 36
• Actual Study Completion Date: October 23, 2019
• Actual Primary Completion Date: October 23, 2019 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

• Subjects > 18 years old and able to give their informed consent.
• Patients diagnosed with Neuroendocrine Tumor of pancreatic origin and histologically confirmed, G1/2 according to the World Health Organization (WHO) classification (Ki67 <20% and/or mitotic count >20 mitoses x 10 HPF).
• Metastatic disease progression in the 12 months prior to baseline visit documented by CT, MRI or Octreoscan.
• Progression to prior treatment with sunitinib administered for metastatic disease and have received at least 1 line and no more than 2 lines of subsequent systemic treatment.
• Measurable disease according to the following criteria RECIST version 1.1
• No disease that can be treated with surgery, radiotherapy or combined treatment with curative intent.
• Eastern Cooperative Oncology Group (ECOG) 0-2.
• Pretreatment with somatostatin analogues, chemotherapy, anti-VEGF (vascular endothelial growth factor) and mTOR (mammalian target of rapamycin) inhibitors prior to participation in the study is allowed.
• Adequately controlled blood pressure (BP) <150/90 mmHg.
• Hematologic Function: - Absolute neutrophil count >1500 / microliter (uL) - Platelets >100,000 / uL - Hemoglobin >5.6 mmol / L (9 g / dL)
• Liver function: total bilirubin < 1.5 x upper limit of normal (ULN), unless unconjugated hyperbilirubinemia or Gilbert syndrome. - Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 2.5 x ULN (< 5 times in case of liver metastases).
• Renal function: calculated creatinine clearance according to Cockcroft-Gault > 30 ml / min.
• Blood coagulation: prothrombin time (PT) or International Normalized Ratio (INR) < 1.2 x ULN.
• Proteinuria <2+ urine dipstick. If > 2+ proteinuria, urinary protein <1 g / 24 h.
• Life expectancy> 3 months.
• Patient able to swallow the study drug and comply with the monitoring requirements of the study. - Women of childbearing potential must present a negative pregnancy test. Women of childbearing potential must agree to use contraception.
• Men whose partners are women of childbearing potential must use effective contraception.

Exclusion Criteria:

• Neuroendocrine tumors of pancreatic origin G3 according to WHO classification.
• Patients who received 3 or more lines of systemic treatment.
• Major surgery or trauma within 4 weeks prior to the first dose of sunitinib.
• Radiation therapy or tumor embolization within 2 weeks prior to the first dose of sunitinib.
• Chemotherapy, immunotherapy, biologic therapy or investigational therapy within the previous 2 weeks or 5 half-lives of the drug last received before the start of the first dose of sunitinib treatment.
• Prior treatment with high-dose chemotherapy that required hematopoietic rescue.
• Immunosuppressive therapy or prolonged treatment with corticosteroids concomitantly administered in the previous 3 months.
• Resolution to grade <2 (CTCAE according V4.03) of all previous related toxicities except alopecia treatments.
• Any ongoing toxicity from prior anti-cancer therapy that is >Grade 1 (according CTCAE V4.03) and/or that is progressing in severity, except alopecia.
• Treatment with potent inhibitors or inducers of CYP3A4 or known to prolong the QT interval in the previous 7 days.
• Prior radiotherapy to more than 25% of the bone marrow - Presence of uncontrolled metastatic brain disease, spinal cord compression, meningeal carcinomatosis or leptomeningeal disease.
• Any gastrointestinal malabsorption disorder or any other condition that, at investigator's criteria, may affect the absorption of sunitinib or increase the risk of bleeding or perforation.
• Presence of any non-healing wound or ulcer.
• Grade III/IV diarrhea in the screening period.
• Diagnosis of any second malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or in situ carcinoma of the cervix uteri.
• Clinically significant cardio/cerebrovascular disease in the 6 months prior to treatment.
• Cardiac arrhythmias (NCI CTCAE version 4.0 grade >2), atrial fibrillation of any grade that requires medical treatment.
• Corrected QT interval (QTcF) > 180 msec.
• Active hemoptysis in the past 6 weeks.
• Evidence of active bleeding or bleeding diathesis.
• Presence of endobronchial lesions and/or lesions that infiltrate large vessels.
• Current treatment with acenocoumarol at therapeutic doses.
• Known HIV infection.
• Presence of uncontrolled active infection.
• Pregnant or breastfeeding women.
• Previous allergic reaction to components structurally similar to sunitinib or any of the excipients.
• Inability to discontinue any prohibited concomitant medication.
• Any illness (medical or psychiatric) or reason, in the investigator's opinion, that interferes with the patient's ability to participate.

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: Spain

Administrative Information

• NCT Number: NCT02713763
• Other Study ID Numbers: GETNE-2016-01; 2015-005774-37 ( EudraCT Number )
• Has Data Monitoring Committee: No

U.S. FDA-regulated Product

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

• IPD Sharing Statement: Not Provided
• Responsible Party: Grupo Espanol de Tumores Neuroendocrinos
• Study Sponsor: Grupo Espanol de Tumores Neuroendocrinos

Collaborators

• Pfizer
• Apices Soluciones S.L.

Investigators

• Principal Investigator: Enrique Grande; MD Anderson Cancer Center MADRID

• PRS Account: Grupo Espanol de Tumores Neuroendocrinos
• Verification Date: March 2020