ABT-199 & Ibrutinib in Mantle Cell Lymphoma (AIM) (AIM)

• ClinicalTrials.gov Identifier: NCT02471391
• Recruitment Status: Active, not recruiting
• First Posted: June 15, 2015
• Last Update Posted: March 20, 2023
• Sponsor: Peter MacCallum Cancer Centre, Australia
• Information provided by (Responsible Party): Peter MacCallum Cancer Centre, Australia

Tracking Information

• First Submitted Date: May 12, 2015
• First Posted Date: June 15, 2015
• Last Update Posted Date: March 20, 2023
• Actual Study Start Date: July 22, 2015
• Estimated Primary Completion Date: June 2023 (Final data collection date for primary outcome measure)
• Current Primary Outcome Measures (submitted: June 10, 2015): Complete response measured using IWG at 16 weeks [ Time Frame: Measured at 16 weeks after commencement of treatment. ]
• Original Primary Outcome Measures: Same as current

Current Secondary Outcome Measures (submitted: June 14, 2015)

• Completing 4, 16, 28, 40 and 56 weeks of treatment [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Toxicities measured using CTCAE version 4 [ Time Frame: Continuously measured while on treatment up to a maximum of 56 weeks ]
• Overall response (CR + PR) using IWG criteria at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Complete response using IWG criteria at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Minimal residual disease (MRD) at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Progression free survival [ Time Frame: From start of treatment until the date of first documented progression or date of death from any cause, whichever occures first, assessed up to the date when the last patient has their 13 months assessment. ]
• Overall survival [ Time Frame: From start of treatment until the date of death from any cause assessed up to the date when the last patient has their 13 months assessment. ]
• Duration of response [ Time Frame: From first disease response date to the date of earliest recurrance or PD, assessed up to the date when the last patient has their 13 months assessment. ]
• Time to progression [ Time Frame: From start of treatment until the date of first documented progression assessed up to the date when the last patient has their 13 months assessment. ]

Original Secondary Outcome Measures (submitted: June 10, 2015)

• Completing 4, 16, 28, 40 and 56 weeks of treatment [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Toxicities measured using CTCAE version 4 [ Time Frame: Continuosly measured during the treatment period. ]
• Overall response (CR + PR) using IWG criteria at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Complete response using IWG criteria at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Minimal residual disease (MRD) at 4, 16, 28, 40 and 56 weeks [ Time Frame: Assessed at 4, 16, 28, 40 and 56 weeks ]
• Progression free survival [ Time Frame: From start of treatment until the date of first documented progression or date of death from any cause, whichever occures first, assessed up to the date when the last patient has their 13 months assessment. ]
• Overall survival [ Time Frame: From start of treatment until the date of death from any cause assessed up to the date when the last patient has their 13 months assessment. ]
• Duration of response [ Time Frame: From first disease response date to the date of earliest recurrance or PD, assessed up to the date when the last patient has their 13 months assessment. ]
• Time to progression [ Time Frame: From start of treatment until the date of first documented progression assessed up to the date when the last patient has their 13 months assessment. ]

• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: ABT-199 & Ibrutinib in Mantle Cell Lymphoma (AIM)
• Official Title: A Phase 2 Study of ABT-199 in Combination With Ibrutinib in the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma (AIM Study)

Brief Summary

This research will test the combination of two new drugs, called ibrutinib and ABT199, taken together in the treatment of Mantle Cell Lymphoma. Other studies have indicated the potential for these drugs to be used in the treatment of participants with Mantle Cell Lymphoma. In this study, the investigators will test the combination of the two drugs together, in order to determine what effects (good and bad) it has on mantle cell lymphoma.

This study has two phases. The first phase is the Primary Evaluation Phase and will closely monitor the effects of ibrutinib and ABT199 for a period of 13 months. Participants who complete 13 months of treatment and continue benefiting from the study treatments will be allowed to continue both drugs until progression or intolerance in the Continuation Phase. The purpose of this phase is to provide patients with continuing access to both ibrutinib and ABT199. Patients will receive routine care from clinician, who will record any sideeffects that may be experienced.

This is one of the first trials in the world to study the combination of ibrutinib and ABT199 together. Therefore the effectiveness of the combination of the study drugs will be assessed, as will how they affect mantle cell lymphoma and how it develops resistance to the treatments. The investigators also do not know whether combining the two drugs together will cause unexpected side effects. Therefore, the study will monitor patients closely and perform scans, blood tests, bone marrow biopsies and other tests at regular intervals.

• Detailed Description: Not Provided
• Study Type: Interventional
• Study Phase: Phase 2
• Study Design: Allocation: N/A; Intervention Model: Single Group Assignment; Masking: None (Open Label); Primary Purpose: Treatment
• Condition: Mantle Cell Lymphoma

Intervention

• Drug: ABT-199
• Drug: Ibrutinib

Study Arms

Experimental: Ibrutinib + ABT-199

Interventions:

• Drug: ABT-199
• Drug: Ibrutinib

Publications *

• Davis JE, Handunnetti SM, Ludford-Menting M, Sharpe C, Blombery P, Anderson MA, Roberts AW, Seymour JF, Tam CS, Ritchie DS, Koldej RM. Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy. Blood Adv. 2020 Oct 13;4(19):4849-4859. doi: 10.1182/bloodadvances.2020002810.
• Tam CS, Anderson MA, Pott C, Agarwal R, Handunnetti S, Hicks RJ, Burbury K, Turner G, Di Iulio J, Bressel M, Westerman D, Lade S, Dreyling M, Dawson SJ, Dawson MA, Seymour JF, Roberts AW. Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma. N Engl J Med. 2018 Mar 29;378(13):1211-1223. doi: 10.1056/NEJMoa1715519.

Recruitment Information

• Recruitment Status: Active, not recruiting
• Actual Enrollment (submitted: May 1, 2022): 37
• Original Estimated Enrollment (submitted: June 10, 2015): 24
• Estimated Study Completion Date: June 2023
• Estimated Primary Completion Date: June 2023 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

1. Subject must be >/= 18 years of age.
2. Subject must have a confirmed diagnosis of Mantle Cell Lymphoma (MCL) according to WHO (2008) criteria, and have received at least one prior line of systemic therapy for MCL.
3. Subject requires treatment in the opinion of the investigator, and has at least one site of radiographically assessable disease not previously irradiated (lymph node with largest diameter >/= 1.5cm, or unequivocal hepatomegaly / splenomegaly)
4. Subject has an Eastern Cooperative Oncology Group (ECOG) performance score of </= 2.

5. Subject must have adequate bone marrow function at Screening as follows:

   • Absolute Neutrophil Count (ANC) >/= 1.0 x 109/L (neutropenia due to marrow infiltration may be supported by growth factors);
   • Platelets >/= 50 x 109/L (entry platelet count must be independent of transfusion within 7 days).

6. Subject must have adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening as follows:

   • aPTT and PT not to exceed 1.5 × the upper limit of normal (ULN);
   • Serum creatinine not to exceed 2 x ULN, and a calculated creatinine clearance of at least 50 mL/min using the Cockcroft-Gault equation or a 24-hour urine collection;
   • AST or ALT </= 3.0 × the upper normal limit (ULN) of institution's normal range; Bilirubin </= 1.5 × ULN. Subjects with documented Gilbert's Syndrome may have a bilirubin > 1.5 × ULN.

7. Female subjects of childbearing potential and non-sterile male subjects (with partners of child bearing potential) must practice at least one of the following methods of birth control with partner(s) from initial study drug administration to 90 days after the last dose of study drug:

   • Total abstinence from sexual intercourse as the preferred life style of the subject; periodic abstinence is not acceptable;
   • Surgically sterile partner(s); acceptable sterility surgeries are: vasectomy, bilateral tubal ligation, bilateral oophorectomy or hysterectomy;
   • Intrauterine device (IUD);
   • Double-barrier method (contraceptive sponge, diaphragm or cervical cap with spermicidal jellies or cream AND a condom);
   • Hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months prior to study drug administration.
8. Female subjects of childbearing potential must have a negative serum (beta-human chorionic gonadotropin [B-hCG]) or urine pregnancy test at Screening. Women who are pregnant or breastfeeding are ineligible for this study
9. Male subjects must agree to refrain from sperm donation, from initial study drug administration until 90 days after the last dose of study drug.
10. Subject is able to swallow whole tablets.
11. Subject (or their legally-acceptable representatives) must sign an informed consent document indicating that they understand the purpose of and procedures required for the study, including biomarkers, and are willing to participate in the study.

Exclusion Criteria:

1. Subject has undergone an allogeneic stem cell transplant within the last 6 months or currently has active graft-vs-host disease requiring the use of immunosuppressants.
2. Subject has active and uncontrolled autoimmune cytopenias (for 2 weeks), including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP).
3. Subject has known central nervous system involvement by MCL.
4. Subject previously participated in an ibrutinib clinical trial or subject previously received a Bruton's tyrosine kinase (BTK) inhibitor other than ibrutinib

5. Subject has received the following within 30 days prior to the first dose of study drug:

   •Monoclonal antibody given with anti-neoplastic intent.

6. Subject has received any of the following within 14 days prior to the first dose of study drug, or has not recovered to less than CTC grade 2 clinically significant adverse effect(s)/toxicity(s) of the previous therapy:

   • Any anti-cancer therapy including chemotherapy, or radiotherapy;
   • Investigational therapy, including targeted small molecule agents.

7. Subject has received the following within 7 days prior to the first dose of study drug:

   •Steroid therapy given with anti-neoplastic intent

8. Subjects requires ongoing therapy with:

   • Potent CYP3A inhibitors (such as indinavir, ketoconazole, and clarithromycin),
   • Potent CYP3A inducers (e.g., rifampin, phenytoin, carbamazepine or St. John's Wort),
   • Warfarin, or or equivalent vitamin K antagonist (eg, phenprocoumon),
   • Antiretroviral medications.

9. Subject has consumed the following within 3 days prior to the first dose of study drug.

   • Grapefruit, or
   • Grapefruit products, or
   • Seville oranges (including marmalade containing Seville oranges), or
   • Star fruit
10. Subject has clinically significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of Screening, or any Class 3 (moderate) or Class 4 (severe) cardiac disease as defined by the New York Heart Association Functional Classification.

11. Subject has a life-threatening illness, medical condition, or organ system dysfunction which, in the investigator's opinion, could compromise the subject's safety, interfere with the absorption or metabolism of ibrutinib capsules, or put the study outcomes at undue risk.

    •specifically, a subject with history of stroke or intracranial hemorrhage within 6 months prior to enrollment is excluded

12. Subject has a history of other active malignancies other than MCL within the past 2 years prior to study entry, with the exception of:

    • Adequately treated in situ carcinoma of the cervix uteri,
    • Adequately treated basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin,
    • Previous malignancy confined and surgically resected (or treated with other modalities) with curative intent.
13. Subject has known history of human immunodeficiency virus (HIV) or active Hepatitis C Virus or active Hepatitis B Virus infection or any uncontrolled active systemic infection requiring intravenous (IV) antibiotics.
14. Received live, attenuated vaccines within 4 weeks of first dose of ibrutinib
15. Major surgery within 4 weeks of first dose of ibrutinib

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: Australia

Administrative Information

• NCT Number: NCT02471391
• Other Study ID Numbers: 14/148
• Has Data Monitoring Committee: Yes
• U.S. FDA-regulated Product: Not Provided
• IPD Sharing Statement: Not Provided
• Current Responsible Party: Peter MacCallum Cancer Centre, Australia
• Original Responsible Party: Same as current
• Current Study Sponsor: Peter MacCallum Cancer Centre, Australia
• Original Study Sponsor: Same as current
• Collaborators: Not Provided
• Investigators: Not Provided
• PRS Account: Peter MacCallum Cancer Centre, Australia
• Verification Date: March 2023