We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Epidemiology of Sepsis in China

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02448472
First Posted: May 19, 2015
Last Update Posted: February 17, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jianfeng Xie, Southeast University, China
April 11, 2015
May 19, 2015
February 17, 2016
November 2015
December 2015   (Final data collection date for primary outcome measure)
  • Incidence [ Time Frame: Patients will be assessed up to 90 days ]
  • Mortality [ Time Frame: Sepsis and severe sepsis patients will be assessed up to 90 days ]
Same as current
Complete list of historical versions of study NCT02448472 on ClinicalTrials.gov Archive Site
etiology [ Time Frame: The pathogen of sepsis will be assessed up to 90 days ]
Same as current
Not Provided
Not Provided
 
Epidemiology of Sepsis in China
Chinese Epidemiological Study of Severe Sepsis.(CHESS Study)
Sepsis is a common cause for morbidity and mortality in critically ill patients. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails. In addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. In China, the MDRO is much higher than western country. There is no study about the epidemiology of sepsis in China. Therefore, it is necessary to conduct a study about it in China.

Sepsis,especially severe sepsis is a major cause of admission to the intensive care unit (ICU) and death. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails. Between 6 and 54% of patients admitted to ICUs have severe sepsis and the mortality rate for these patients varies from 20 to 60%. There is no exactly results of incidence of sepsis in China.

In addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. In EPIC II study, the organisms of sepsis include Gram-positive microorganisms (69.8%),Gram-negative microorganisms(62.2%) and fungi (17%). In China, the MDRO is much higher than western country. In contrast to EPIC II study, one study in China showed that the organisms of sepsis include Gram-positive microorganisms (14.5%),Gram-negative microorganisms(62.5%) and fungi (2.2%). Therefore, it is necessary to conduct a study about epidemiology of sepsis in China.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample
Sepsis patient who admitted into ICU
Sepsis
Other: Observational study, none intervention
Not Provided
Yang Y, Xie JF, Yu KJ, Yao C, Li JG, Guan XD, Yan J, Ma XC, Kang Y, Yang CS, Yao XQ, Shang HC, Qiu HB; for CHESS Study Investigators. Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey. Chin Med J (Engl). 2016 Dec 20;129(24):2967-2973. doi: 10.4103/0366-6999.195474.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
2000
January 2016
December 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

sepsis patients who admitted into ICU during research period (include patients with sepsis at ICU admission and patients who has new sepsis during ICU period)

Exclusion Criteria:

The patients with second sepsis in ICU

Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
China
 
 
NCT02448472
20150315
Yes
Not Provided
Not Provided
Jianfeng Xie, Southeast University, China
Jianfeng Xie
Not Provided
Study Director: Yang Yi, Ph.D. Zhongda hospital, Southeast University
Southeast University, China
October 2015