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Metabolic Exercise Testing (RANNOU)

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ClinicalTrials.gov Identifier: NCT02362685
Recruitment Status : Recruiting
First Posted : February 13, 2015
Last Update Posted : January 31, 2017
Sponsor:
Information provided by (Responsible Party):
RANNOU, University Hospital, Brest

February 4, 2015
February 13, 2015
January 31, 2017
September 2008
December 2018   (Final data collection date for primary outcome measure)
  • Whole-body dynamic exercise [ Time Frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed ]
    The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
  • Grip-test [ Time Frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed ]
    The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
  • Blood tests [ Time Frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed ]
    The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.
Same as current
Complete list of historical versions of study NCT02362685 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
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Metabolic Exercise Testing
Exercise Testing in Metabolic Myopathies
Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Blood sample Urine sample Muscle tissue DNA
Non-Probability Sample
Subjects referred to perform a metabolic exercise testing.
  • Metabolic Myopathies
  • Exercise Test
  • Myalgia
  • Device: functional test
    subjects perform a metabolic exercise testing
  • Genetic: matching genotype with phenotype
metabolic exercise testing
All the subjects referred to performed a metabolic exercise testing.
Interventions:
  • Device: functional test
  • Genetic: matching genotype with phenotype
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
Same as current
December 2018
December 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
  • Ability to provide informed consent

Exclusion Criteria:

  • Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
  • Pregnancy or unknown pregnancy status.
Sexes Eligible for Study: All
5 Years and older   (Child, Adult, Older Adult)
Yes
Contact: Fabrice Rannou, MD, PhD 33(0)298347366 fabrice.rannou@chu-brest.fr
France
 
 
NCT02362685
RANNOU
No
Not Provided
Not Provided
RANNOU, University Hospital, Brest
University Hospital, Brest
Not Provided
Principal Investigator: Fabrice Rannou, MD, PhD CHRU Brest
University Hospital, Brest
January 2017