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Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02196870
First Posted: July 22, 2014
Last Update Posted: June 24, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jianfeng Xie, Southeast University, China
July 12, 2014
July 22, 2014
June 24, 2015
July 2014
June 2015   (Final data collection date for primary outcome measure)
Changes of oxygenation and lung mechanics [ Time Frame: up to 24 months ]
Same as current
Complete list of historical versions of study NCT02196870 on ClinicalTrials.gov Archive Site
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Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)
Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Observational [Patient Registry]
Observational Model: Case Control
Time Perspective: Prospective
3 Years
Not Provided
Probability Sample
acute respiratory failure patients
  • Airway Pressure Stress Index
  • Transpulmonary Pressure Stress Index
  • Acute Respiratory Failure
  • Chest Wall Elastance
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Pan C, Chen L, Zhang YH, Liu W, Urbino R, Ranieri VM, Qiu HB, Yang Y. Physiological Correlation of Airway Pressure and Transpulmonary Pressure Stress Index on Respiratory Mechanics in Acute Respiratory Failure. Chin Med J (Engl). 2016 Jul 20;129(14):1652-7. doi: 10.4103/0366-6999.185855.
 
Completed
12
June 2015
June 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • ARF
  • mechanical ventilation
  • cardiovascular stable

Exclusion Criteria:

  • age < 18y or > 85y
  • pregnancy
  • COPD or chronic pulmonary disease
Sexes Eligible for Study: All
18 Years to 85 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
China
 
 
NCT02196870
Chest wall Elastance in ARF
Yes
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Jianfeng Xie, Southeast University, China
Southeast University, China
Not Provided
Principal Investigator: Jianfeng Xie, Dr. Zhongda hospital, Southeast University, Jiangsu, China
Southeast University, China
June 2015