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Longitudinal Study of Brain Amyloid imaGing in MEMENTO (MEMENTOAmyGing)

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ClinicalTrials.gov Identifier: NCT02164643
Recruitment Status : Active, not recruiting
First Posted : June 16, 2014
Last Update Posted : February 28, 2018
Sponsor:
Collaborators:
Fondation Plan Alzheimer
GE Healthcare
Avid Radiopharmaceuticals
Information provided by (Responsible Party):
University Hospital, Bordeaux

June 12, 2014
June 16, 2014
February 28, 2018
June 10, 2014
December 2018   (Final data collection date for primary outcome measure)
Progression to clinical dementia stage according to standardized classifications (DSM-IV and NINCDS-ADRDA) as described in the MEMENTO protocol. [ Time Frame: 24 months from baseline ]
Same as current
Complete list of historical versions of study NCT02164643 on ClinicalTrials.gov Archive Site
  • Longitudinal evolution of amyloid load measured through either Florbetapir (18F) or Flutemetamol (18F) [ Time Frame: 24 months from baseline ]
  • Speed of cognitive decline based on change in cognitive performances [ Time Frame: 24 months from baseline ]
  • Longitudinal evolution of biomarkers measured from blood, CSF, structural neuroimaging (MRI) and glucose metabolism molecular neuroimaging (18F-FDG PET). [ Time Frame: 24 months from baseline ]
  • Mortality [ Time Frame: 24 months from baseline ]
  • Loss of autonomy based on functional activity assessment [ Time Frame: 24 months from baseline ]
  • Institutionalization [ Time Frame: 24 months from baseline ]
  • Cardiovascular event (Stroke and Coronary events) [ Time Frame: 24 months from baseline ]
  • Quality of life [ Time Frame: 24 months from baseline ]
  • Prodromal AD (Pre-symptomatic dementia) [ Time Frame: 24 months from the baseline ]
  • Etiology of dementia, when converted [ Time Frame: 24 months from the baseline ]
Same as current
Not Provided
Not Provided
 
Longitudinal Study of Brain Amyloid imaGing in MEMENTO
Longitudinal Study of Brain Amyloid imaGing in MEMENTO
A Multicenter national longitudinal cohort study including at least 800 individuals consecutively recruited from French Research Memory Centers and followed-up over 24 month and included in Memento.

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting approximately 7.3 million people in Europe. AD is a clinicopathologic entity for which the definitive diagnosis requires both the presence of the clinical signs of dementia and pathological evidence of amyloid plaque in the brain (obtained at autopsy).

Currently, diagnosis of AD at early stage of the disease is hampered by the lack of noninvasive and validated biomarkers of the underlying pathology. On one hand, it is suggested that between 10% and 20% of patients currently diagnosed with AD, based on clinical evidence solely, lack AD pathology at autopsy, and on the other hand community physicians may not diagnose AD in 33% of patients with mild signs and symptoms. Thus, there is a need for validated diagnostic biomarker that could help clinicians separate patients who do not have AD from those who have pathological signs and should be referred for further evaluation and care management. Furthermore, little is known on the prognosis value for dementia conversion of current biomarkers of AD pathology at a preclinical or presymptomatic stage.

Recently, 18F-labeled positron emission tomography (PET) imaging agents have been developed that bind with high affinity to the amyloid-β (Aβ) peptide fibrils that constitute amyloid plaques, and thus, have potential value as an imaging biomarkers for amyloid deposits in subjects with cognitive impairment or isolated cognitive complaints.

The principal objective of this ancillary study is to investigate the prospective association between PET amyloid load, measured twice two years apart, through either Florbetapir (18F) or Flutemetamol (18F) radioligands, and dementia incidence over up to 5 years of follow-up in a sample of individuals presenting with a spectrum of cognitive profiles ranging from isolated cognitive complaints to cognitive deficits without dementia.

The secondary objectives are the following:

  • To assess the association between change in amyloid load and clinical evolution of participants (both functional and cognitive)
  • To estimate the prevalence of new research criteria for preclinical Alzheimer's disease
  • To investigate long-term outcome of preclinical Alzheimer's disease according to NIA-AA criteria
  • To assess the determinants of change in amyloid load over two years
  • To study the interrelationships between biomarkers
  • To assess the added value of amyloid binding agent (Florbetapir (18F) and Flutemetamol (18F)) in combination with other biomarkers (neuropsychological, genetics, plasma, serum, CSF, structural neuroimaging, 18F-FDG-PET) to predict clinical dementia onset
  • To assess the diagnostic accuracy of amyloid agent Florbetapir (18F) and Flutemetamol (18F) to differentiate AD from other types of dementia (differential diagnosis)
  • To study the link between amyloid binding agent and survivalstudy design
Interventional
Phase 3
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Alzheimer's Disease (AD) and Related Disorders
  • Drug: Flutemetamol (18F)
  • Drug: Florbetapir (18F)
  • Experimental: Florbetapir (18F)
    Intervention: Drug: Florbetapir (18F)
  • Experimental: Flutemetamol (18F)
    Intervention: Drug: Flutemetamol (18F)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
448
800
December 2018
December 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • To be included in MEMENTO
  • To have signed a specific MEMENTO-AmyGing informed consent form, prior to any amyloid PET procedures
  • To have had or agreed to have 18F-FDG PET scan in MEMENTO
  • To tolerate the (18F) PET scan procedures, in the opinion of the clinical site investigator
  • Clinical Dementia Rating scale <0.5 and not demented

Exclusion Criteria:

  • To have a current clinically significant psychiatric condition that neurologists/geriatricians feel would preclude the ability to have a research PET scan
  • To be pregnant or breastfeading women
  • To have Hypersensitivity to the tracer or to the excipient listed in the summary of the product carateristics (florbetapir Amyvid®) or the Investigator's Brochure (flutemetamol)
  • To have a relevant history of severe drug allergy or hypersensitivity (relevant severe drug allergies should be determined by the clinical site investigator or co-clinical site investigator). If a subject has a history of severe drug allergies, it may be dangerous for them to participate in a study with a novel compound
  • To have ever participated in an experimental study with an amyloid targeting agent (e.g. anti-amyloid immunotherapy, γ-secretase or γ-secretase inhibitor) unless it can be documented that the subject received only placebo during the course of the trial
  • To receive any investigational medications, or have participated in a trial with investigational medications within the last 30 days
  • To have participated less than 1 year ago in a biomedical research with injection of one of the amyloid radioligand or to be enrolled in an ongoing biomedical research including amyloid PET scan
  • To have had a radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
France
 
 
NCT02164643
CHUBX 2010/47 A
No
Not Provided
Not Provided
University Hospital, Bordeaux
University Hospital, Bordeaux
  • Fondation Plan Alzheimer
  • GE Healthcare
  • Avid Radiopharmaceuticals
Principal Investigator: Genevieve CHENE, Prof CIC-EC7 - ISPED - CHU de Bodeaux
Study Chair: Geneviève CHENE, Prof CIC-EC7 - ISPED - CHU de Bordeaux
Study Director: Carole DUFOUIL, Director CIC-EC7 - ISPED - CHU de Bordeaux
Study Director: Florence PASQUIER, Prof Head of Lille Memory Clinic, CHRU Lille
Study Director: Marie-Odile HABERT, Prof Head of Molecular Imaging Work package for the Center for Image Acquisition and Processing - CHU Pitié-Salpêtrière, AP-HP
University Hospital, Bordeaux
February 2018

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP