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Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2012 by Xiaohua Qiu, Zhongda Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT02060773
First Posted: February 12, 2014
Last Update Posted: February 12, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Xiaohua Qiu, Zhongda Hospital
February 8, 2014
February 12, 2014
February 12, 2014
December 2012
February 2014   (Final data collection date for primary outcome measure)
ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT. [ Time Frame: 30 hours ]
Same as current
No Changes Posted
28 days mortality [ Time Frame: 28 days ]
Follow up to determine the mortality in 28 days after inclusion
Same as current
Not Provided
Not Provided
 
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.

Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample
Critical patients with early septic shock admitted to ICU within 24 hours after onset
Septic Shock
Not Provided
Not Provided
Zhang XW, Xie JF, Liu AR, Huang YZ, Guo FM, Yang CS, Yang Y, Qiu HB. Hepatic Perfusion Alterations in Septic Shock Patients: Impact of Early Goal-directed Therapy. Chin Med J (Engl). 2016 Jul 20;129(14):1666-73. doi: 10.4103/0366-6999.185865.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
Not Provided
February 2014
February 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. patients with septic shock
  2. at least one of the EGDT criteria not achieved
  3. informed consent accepted

Exclusion Criteria:

  1. ages below 18 or above 90
  2. pregnancy
  3. the time elapsed over 24 hours after onset of septic shock
  4. chronic liver disease
  5. terminal stage of disease
  6. brain death
  7. other types of shock
  8. brain injury
  9. allergic to iodine or indocyanine
Sexes Eligible for Study: All
18 Years to 90 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
China
 
 
NCT02060773
zhongdaH
No
Not Provided
Not Provided
Xiaohua Qiu, Zhongda Hospital
Zhongda Hospital
Not Provided
Not Provided
Zhongda Hospital
December 2012