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The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

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ClinicalTrials.gov Identifier: NCT02000076
Recruitment Status : Completed
First Posted : December 3, 2013
Last Update Posted : May 16, 2016
Sponsor:
Collaborator:
Stockholm University
Information provided by (Responsible Party):
Mats Lekander, Karolinska Institutet

August 13, 2013
December 3, 2013
May 16, 2016
November 2012
March 2014   (Final data collection date for primary outcome measure)
Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping) [ Time Frame: Change between 1st and 2nd MRI scanning session (approx. 1 month later) ]
This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).
Same as current
Complete list of historical versions of study NCT02000076 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old
The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old
The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.
Not Provided
Interventional
Not Applicable
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Sleep Deprivation
  • Behavioral: Partial sleep deprivation allowing 3 h sleep at night
    Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
    Other Names:
    • Sleep restriction
    • Sleep loss
  • Behavioral: Full sleep
    Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
  • Experimental: Sleep deprivation
    Partial sleep deprivation allowing 3 h sleep at night
    Intervention: Behavioral: Partial sleep deprivation allowing 3 h sleep at night
  • Experimental: Full sleep
    Sleep with no restriction
    Intervention: Behavioral: Full sleep
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
98
30
May 2014
March 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 20-30 years of age, inclusive OR 65-75 years of age, inclusive
  • Able to understand spoken and written Swedish (in order to understand instructions)
  • Normal or corrected-to-normal vision not using glasses
  • Not colour blind
  • Right-handed
  • Free from ferromagnetic objects in body
  • No history of any neurologic or psychiatric illness including drug abuse
  • No history of diabetes nor hypertension

    • No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
    • No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
  • No use of psychotropic drugs
  • Not studying or working in medicine, psychology, nor behavioural science
  • Not suffering from severe seasonal allergy
  • No use of cortisone, anti-histamines, nor any other immune-modulating drugs
  • Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine
  • No daily use of nicotine

Exclusion Criteria:

Sexes Eligible for Study: All
20 Years to 75 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Sweden
 
 
NCT02000076
Sleepy Brain Study Wave 1
No
Not Provided
Plan to Share IPD: Yes
Plan Description: De-identified individual participant data will be shared through the openfmri.org data repository.
Mats Lekander, Karolinska Institutet
Mats Lekander
Stockholm University
Study Chair: Torbjörn Åkerstedt, PhD Stockholm University
Principal Investigator: Mats Lekander, PhD Stockholm University, Karolinska Institutet
Principal Investigator: Håkan Fischer, PhD Stockholm University
Karolinska Institutet
May 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP