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Postprandial VLDL-TG Metabolism

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01961024
First Posted: October 11, 2013
Last Update Posted: May 3, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus
September 27, 2013
October 11, 2013
May 3, 2017
January 2014
August 2015   (Final data collection date for primary outcome measure)
VLDL-TG storage in adipose tissue [ Time Frame: 3 hours ]
Same as current
Complete list of historical versions of study NCT01961024 on ClinicalTrials.gov Archive Site
18F-THA fractional storage [ Time Frame: 6 Hours ]
Same as current
Not Provided
Not Provided
 
Postprandial VLDL-TG Metabolism
Postprandial VLDL-TG Metabolism
In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
specimen of muscle specimen of adipose tissue
Non-Probability Sample
Males with diabetes from the department´s out-patient clinic. Control group of healthy volunteers
Type 2 Diabetes
Not Provided
  • Type 2 diabetic men
  • Age- and weight-matched controls
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
21
August 2015
August 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
Sexes Eligible for Study: Male
30 Years to 70 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT01961024
ES-0006
Yes
Not Provided
Not Provided
Esben Søndergaard, University of Aarhus
University of Aarhus
Not Provided
Not Provided
University of Aarhus
May 2017