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Effects of White Rice, Brown Rice, and Black Rice on Postprandial Glucose and Lipid Profiles in Healthy Korean Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Soo-Wan Chae, Chonbuk National University Hospital
ClinicalTrials.gov Identifier:
NCT01932086
First received: August 21, 2013
Last updated: August 30, 2013
Last verified: August 2013
August 21, 2013
August 30, 2013
March 2011
April 2011   (Final data collection date for primary outcome measure)
1. Glucose, insulin AUC(incremental area under the curve) 2. Glycemic index(GI) [ Time Frame: 2 hour postprandial blood glucose, insulin ]
  1. Plasma glucose and insulin will be measured at baseline, 15, 30, 45, 60, 90, 120, 180 and 240 minutes post ingestion of each test solution, and area under the curve will be calculated.
  2. Glycemic index (GI) was defined as the area under the glucose response curve after consumption of a test food divided by the area under the curve after consumption of a control food containing the same amount of carbohydrate and calculated using 50 g glucose as the reference. Plasma glucose will be measured at baseline, 15, 30, 45, 60, 90, and 120 minutes post ingestion of each test solution.

GI= (incremental blood glucose area of test meal/incremental area of glucose) × 100

Same as current
Complete list of historical versions of study NCT01932086 on ClinicalTrials.gov Archive Site
Triglyceride iAUC(incremental area under the curve) [ Time Frame: 6 hour postprandial blood triglyceride(TG) ]
Triglyceride will be measured at baseline, 0, 1, 2, 3, 4, 5 and 6 hours post ingestion of each test solution, and area under the curve will be calculated.
Same as current
Homeostatic model assessment-insulin resistance(HOMA-IR), quantitative insulin sensitivity check index(QUICKI), Insulinogenic index(IGI) [ Time Frame: fasting and postprandial (different times for 30min) ]
  1. HOMA-IR={fasting insulin(µU/㎖) x fasting glucose(m㏖/L)}/22.5
  2. QUICKI=1/log(insulin 0min)-log(glucose 0min)
  3. IGI=(insulin 30min-fasting insulin)/(glucose 30min-fasting glucose)
Same as current
 
Effects of White Rice, Brown Rice, and Black Rice on Postprandial Glucose and Lipid Profiles in Healthy Korean Adults
A Randomized, Crossover Clinical Trial
This study was an open, 5-treatment, 5-sequence, 5-day cross-over randomized design clinical trial. The present study was carried out to compare the effects of white rice, brown rice, and black rice on postprandial glucose and lipid profiles in healthy human subjects, using a white bread as a positive control.

After a 12-hour fast, oral glucose and meal tolerance was measured with blood samples drawn at times 0, 15, 30, 45, 60, 90, 120, 150 and 180 minutes and TG was at time 0, 1, 2, 3, 4, 5 and 6 hours.

  1. Serum levels of glucose, insulin, and TG were analyzed by biochemical autoanalyzer. The area under the curve (AUC) changes in blood glucose, TG were computed by the trapezoidal method.
  2. Glycemic index(GI): the area under the glucose response curve after consumption of a test food divided by the area under the curve after consumption of a control food containing the same amount of carbohydrate and calculated using 50 g glucose as the reference.
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Healthy
  • Dietary Supplement: White rice diet
    All test foods contained 50 g available carbohydrate from the test food products. A glass of 250 ml water was served together with the clinical trial food, and the participants were instructed to ingest the breakfast with 15 min
  • Dietary Supplement: Brown rice diet
    All test foods contained 50 g available carbohydrate from the test food products. A glass of 250 ml water was served together with the clinical trial food, and the participants were instructed to ingest the breakfast with 15 min
  • Dietary Supplement: Black rice diet
    All test foods contained 50 g available carbohydrate from the test food products. A glass of 250 ml water was served together with the clinical trial food, and the participants were instructed to ingest the breakfast with 15 min
  • Dietary Supplement: Bread
    All test foods contained 50 g available carbohydrate from the test food products. A glass of 250 ml water was served together with the clinical trial food, and the participants were instructed to ingest the breakfast with 15 min
    Other Name: control diet
  • Other: Glucose solution
    All test foods contained 50 g available carbohydrate from the test food products.and the participants were instructed to ingest the breakfast with 10 min.
    Other Name: Reference diet
  • Experimental: White rice
    Interventions:
    • Dietary Supplement: White rice diet
    • Dietary Supplement: Brown rice diet
    • Dietary Supplement: Black rice diet
    • Dietary Supplement: Bread
    • Other: Glucose solution
  • Experimental: Brown rice
    Interventions:
    • Dietary Supplement: White rice diet
    • Dietary Supplement: Brown rice diet
    • Dietary Supplement: Black rice diet
    • Dietary Supplement: Bread
    • Other: Glucose solution
  • Experimental: Black rice
    Interventions:
    • Dietary Supplement: White rice diet
    • Dietary Supplement: Brown rice diet
    • Dietary Supplement: Black rice diet
    • Dietary Supplement: Bread
    • Other: Glucose solution
  • Active Comparator: Bread
    Interventions:
    • Dietary Supplement: White rice diet
    • Dietary Supplement: Brown rice diet
    • Dietary Supplement: Black rice diet
    • Dietary Supplement: Bread
    • Other: Glucose solution
  • Active Comparator: Glucose solution
    Interventions:
    • Dietary Supplement: White rice diet
    • Dietary Supplement: Brown rice diet
    • Dietary Supplement: Black rice diet
    • Dietary Supplement: Bread
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
15
October 2011
April 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Males, 19~60years old
  • Bodyweight was more than 50 kg with ideal body weight within ±30%
  • triglyceride (TG) levels less than 200 mg/dL
  • Fasting blood glucose levels less than 100 mg/dL and an oral glucose tolerance test (OGTT) less than 140 mg/dL
  • Able to give informed consent

Exclusion Criteria:

  • Major medical illness such as cardiovascular, neurologic, psychiatric, renal, pulmonary and hepatic diseases
  • History of disease that could interfere with the test products or impede their absorption such as gastrointestinal disease or gastrointestinal surgery
  • Medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
  • Poor vital sign (systolic blood pressure: below 100 mmHg or above 150 mmHg, diastolic blood pressure: below 65 mmHg or above95 mmHg)
  • Allergic or hypersensitive to any of the ingredients in the test products; treated with any drug within past 2 weeks
  • Participation in any other clinical trials within past 2 months
  • Alcohol consumption above 21 units per week or abnormal screening laboratory test
  • Being judged by the responsible physician of the local study center as unfit to participate in the study
Sexes Eligible for Study: Male
19 Years to 60 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
 
NCT01932086
CTCF2_2011_RP_1
Yes
Not Provided
Not Provided
Not Provided
Soo-Wan Chae, Chonbuk National University Hospital
Chonbuk National University Hospital
Not Provided
Study Director: Soo-Wan Chae, MD., PhD Chonbuk National University Hospital
Chonbuk National University Hospital
August 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP