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Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01897350
First Posted: July 12, 2013
Last Update Posted: October 21, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Elisa McAlindon, University of Bristol
July 8, 2013
July 12, 2013
October 21, 2014
July 2013
December 2013   (Final data collection date for primary outcome measure)
The mass of myocardial oedema measured by CMR [ Time Frame: Day 2 following STEMI ]
Same as current
Complete list of historical versions of study NCT01897350 on ClinicalTrials.gov Archive Site
Extra cellular volume [ Time Frame: Day 2 following STEMI ]
Same as current
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Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial
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Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.
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Observational
Time Perspective: Prospective
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Non-Probability Sample
30 patients will be undergo a CMR scan day 2 following STEMI
  • ST Segment Elevation Myocardial Infarction
  • Myocardial Oedema
Other: Cardiac magnetic resonance imaging
CMR following ST segment myocardial infarction
Intervention: Other: Cardiac magnetic resonance imaging
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
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December 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • STEMI
  • providing written informed consent

Exclusion Criteria:

  • contraindication to CMR,
  • atrial fibrillation,
  • claustrophobia,
  • eGFR < 30
Sexes Eligible for Study: All
18 Years to 85 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01897350
Study 1953
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Elisa McAlindon, University of Bristol
Elisa McAlindon
Not Provided
Not Provided
University of Bristol
October 2014