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Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder (MOTR)

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ClinicalTrials.gov Identifier: NCT01896024
Recruitment Status : Completed
First Posted : July 11, 2013
Last Update Posted : December 2, 2014
Sponsor:
Information provided by (Responsible Party):
Ueli Kramer, University of Lausanne Hospitals

Tracking Information
First Submitted Date  ICMJE July 5, 2013
First Posted Date  ICMJE July 11, 2013
Last Update Posted Date December 2, 2014
Study Start Date  ICMJE June 2010
Actual Primary Completion Date May 2013   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: July 10, 2013)
Outcome Questionnaire -45.2 (Lambert et al., 2004) [ Time Frame: 3 months ]
pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months
Original Primary Outcome Measures  ICMJE Same as current
Change History Complete list of historical versions of study NCT01896024 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures  ICMJE
 (submitted: July 10, 2013)
Inventory of Interpersonal Problems (Horowitz et al., 1988) [ Time Frame: 3 months ]
Measure of interpersonal problems after 3 months of therapy
Original Secondary Outcome Measures  ICMJE Same as current
Current Other Pre-specified Outcome Measures
 (submitted: July 10, 2013)
Borderline Symptom List (Bohus, 2009) [ Time Frame: 3 months ]
Symptom reduction of borderline symptoms over 3 months of treatment
Original Other Pre-specified Outcome Measures Same as current
 
Descriptive Information
Brief Title  ICMJE Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder
Official Title  ICMJE Not Provided
Brief Summary

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder.

The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson & Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post.

The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.

Detailed Description Not Provided
Study Type  ICMJE Interventional
Study Phase  ICMJE Not Applicable
Study Design  ICMJE Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Condition  ICMJE Borderline Personality Disorder
Intervention  ICMJE
  • Behavioral: Psychiatric Management
  • Behavioral: Motive-oriented therapeutic relationship/Plan Analysis
Study Arms  ICMJE
  • Active Comparator: General Psychiatric Management (GPM; Gunderson & Links, 2008)
    psychodynamic-psychiatric treatment for borderline personality disorder
    Intervention: Behavioral: Psychiatric Management
  • Experimental: GPM plus Motive-Oriented Therapeutic Relationship
    use of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM
    Interventions:
    • Behavioral: Psychiatric Management
    • Behavioral: Motive-oriented therapeutic relationship/Plan Analysis
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: July 10, 2013)
85
Original Actual Enrollment  ICMJE Same as current
Actual Study Completion Date  ICMJE April 2014
Actual Primary Completion Date May 2013   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • DSM-IV Borderline Personality Disorder;
  • between 18 and 65 yrs of age

Exclusion Criteria:

  • DSM-IV psychotic disorders,
  • mental retardation,
  • substance abuse in the forefront
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 65 Years   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE Switzerland
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT01896024
Other Study ID Numbers  ICMJE SNSF 100014-134562
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Ueli Kramer, University of Lausanne Hospitals
Study Sponsor  ICMJE University of Lausanne Hospitals
Collaborators  ICMJE Not Provided
Investigators  ICMJE Not Provided
PRS Account University of Lausanne Hospitals
Verification Date December 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP