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Assessment of Coronary Artery Disease in Stroke Patients (ACADIS)

This study has been completed.
Sponsor:
Collaborator:
National Research Foundation of Korea
Information provided by (Responsible Party):
Seoul National University Hospital
ClinicalTrials.gov Identifier:
NCT01850693
First received: May 3, 2013
Last updated: November 8, 2015
Last verified: May 2013

May 3, 2013
November 8, 2015
July 2006
December 2012   (final data collection date for primary outcome measure)
MACE (Major Adverse Cardiac Event) [ Time Frame: Participants will be followed until June. 2015, an expeded average of 5 years ] [ Designated as safety issue: No ]
MACE was included as follows: 1) all-cause mortality, 2) myocardial infarction, 3) unstable angina requiring hospitalization
MACE (Major Adverse Cardiac Event) [ Time Frame: Participants will be followed until Dec. 2013, an expeded average of 5 years ] [ Designated as safety issue: No ]
MACE was included as follows: 1) all-cause mortality, 2) myocardial infarction, 3) unstable angina requiring hospitalization
Complete list of historical versions of study NCT01850693 on ClinicalTrials.gov Archive Site
Any cardiac events [ Time Frame: Participants will be followed until June. 2015, an expeded average of 5 years ] [ Designated as safety issue: No ]
1) late revascularization: who underwent revascularization therapy mroe than 90days after CCTA and referral due ot new symptoms or an abnormal function test, 2) heart failure required hospitalization.
Revascularization [ Time Frame: Participants will be followed until Dec. 2013, an expeded average of 5 years ] [ Designated as safety issue: No ]
However, early revascularization less than 90days after CCTA scan is excluded from events, because these subjects directly affected by CT findings
Repeated stroke [ Time Frame: Participants will be followed until June. 2015, an expeded average of 5 years ] [ Designated as safety issue: No ]
newly developed stroke after CCTA scan
Repeated stroke [ Time Frame: Participants will be followed until Dec. 2013, an expeded average of 5 years ] [ Designated as safety issue: No ]
newly developed stroke after CCTA scan
 
Assessment of Coronary Artery Disease in Stroke Patients
Prevalence and Characteristics of Coronary Atherosclerosis in Stroke Patients Using Coronary CT Angiography
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.

Stroke and coronary artery disease (CAD) share common risk factors and pathological mechanisms. CAD is an important cause of death in patients with stroke.

Currently, coronary CT angiography (CCTA) is very useful non-invasive tool for detection of CAD and plaque analysis.

Therefore, the investigators aimed to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of CAD in stroke patients through follow-up (more than 5 years) using CCTA.

Observational [Patient Registry]
Observational Model: Cohort
5 Years
Not Provided
Non-Probability Sample
Stroke patients on the basis of TOAST classification
Coronary Artery Disease
Not Provided
Coronary artery disease, Stroke
Coronary artery disease, stroke, coronary CT angiography
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1657
June 2015
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Acute stroke patients who diagnosed by clinical and brain MR imaging
  • Who performed coronary CT angiography within 3 months after acute stroke

Exclusion Criteria:

  • intracranial hemorrhage including intracerebral, subdural or subarachnoid hemorrhage
  • brain tumor
  • Previous myocardial infarction
  • Previously performed percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or other cardiac surgery
  • Insufficient medical record
  • Poor image quality of CCTA scan
Both
30 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01850693
NRF 2010-0023504
Yes
Not Provided
Not Provided
Seoul National University Hospital
Seoul National University Hospital
National Research Foundation of Korea
Principal Investigator: Eun Ju Chun, MD Department of Radiology, Seoul National University Bundang Hospital
Seoul National University Hospital
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP