Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft (NOAHS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01838356
Recruitment Status : Completed
First Posted : April 24, 2013
Last Update Posted : January 17, 2018
Information provided by (Responsible Party):
Yale University

April 15, 2013
April 24, 2013
January 17, 2018
September 2012
August 2016   (Final data collection date for primary outcome measure)
Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH. [ Time Frame: 12 months ]
Same as current
Complete list of historical versions of study NCT01838356 on Archive Site
Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests. [ Time Frame: 12 months ]
Neurocognitive tests are aimed at evaluating memory, processing speed, and global cognition.
Same as current
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Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft
Intracranial Atherosclerosis and Predictors of Post-CABG Depression

The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.

The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.

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Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample
The study population for this study will be drawn from cardiac surgery patients at a university-based hospital who will undergo coronary artery bypass graft (CABG) surgery.
  • Depression
  • Intracranial Atherosclerosis
  • Coronary Artery Disease
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No treatment.
Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB. Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. Int Psychogeriatr. 2015 Dec;27(12):1929-38. doi: 10.1017/S1041610215001477. Epub 2015 Oct 2.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
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August 2016   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age: 40 years or older
  • Will be having CABG surgery at the Yale New Haven Hospital
  • Be able to provide informed consent
  • Have a household telephone
  • A fluent English speaker, and possessing no communication barrier
  • Be able to come to the study site or to have the study team come to his/her home.
  • Has a family member or partner/ friend who could provide collateral information

Exclusion Criteria:

  • Has had previous CABG surgery
  • History of dementia diagnosis or cognitive impairment (CDR >/= 1)
  • Auditory or visual impairment that would interfere with study procedures
  • Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items)
  • History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report.
  • Presence of non-cardiovascular conditions likely to be fatal within 1 year
Sexes Eligible for Study: All
40 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
United States
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Yale University
Yale University
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Yale University
January 2018