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Study of the Glycocalyx in Abdominal Aortic Aneurysm (Endo_eAAA)

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ClinicalTrials.gov Identifier: NCT01834092
Recruitment Status : Unknown
Verified April 2013 by Thomas Bech Jorgensen, Rigshospitalet, Denmark.
Recruitment status was:  Recruiting
First Posted : April 17, 2013
Last Update Posted : April 17, 2013
Information provided by (Responsible Party):

April 13, 2013
April 17, 2013
April 17, 2013
April 2013
June 2014   (Final data collection date for primary outcome measure)
Endothelial dysfunction [ Time Frame: 24 hours ]
Measurement of endothelial markers peri- and postoperative: thrombomodulin, E-selectin and syndecan-1
Same as current
No Changes Posted
Fluid balance [ Time Frame: 24 hours ]
Perioperative and postoperative first 24 hours
Same as current
Postoperative organ failure [ Time Frame: 30 days ]
Development of kidney- and respiratory failure and sepsis
Same as current
Study of the Glycocalyx in Abdominal Aortic Aneurysm
Measurement of the Endothelial Function in Patients With a Abdominal Aortic Aneurism.
The investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.

50 patients is scheduled for enrollment. Blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. In addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage.

The first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.

Not Provided
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
  • Abdominal Aortic Aneurism
  • Surgery
  • Ischemic Reperfusion Injury
Other: Plasma
2 Units of plasma transfused equvilant to 2 times 275ml
Other Name: Fresh frozen plasma versus fresh non-frozen plasma
  • Active Comparator: Fresh frozen plasma
    2 portions of FFP will be transfused prior to reperfusion
    Intervention: Other: Plasma
  • Experimental: Fresh non-frozen plasma
    2 portions of non-frozen plasma will be transfused prior to reperfusion
    Intervention: Other: Plasma
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
July 2014
June 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • above 18 years

Exclusion Criteria:

  • prior engagement in scientific study within the last 30 days.
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Thomas Bech Jorgensen, Rigshospitalet, Denmark
Rigshospitalet, Denmark
Not Provided
Study Chair: Per I Johansson, MD Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark.
Rigshospitalet, Denmark
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP