Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01819103
Recruitment Status : Completed
First Posted : March 27, 2013
Last Update Posted : April 4, 2013
Information provided by (Responsible Party):
Oras Alabas, University of Leeds

March 23, 2013
March 27, 2013
April 4, 2013
March 2011
February 2013   (Final data collection date for primary outcome measure)
Mortality [ Time Frame: 12 months ]
Same as current
Complete list of historical versions of study NCT01819103 on Archive Site
Drug Adherence [ Time Frame: 12 month ]
Same as current
Health related quality of life assessement [ Time Frame: 12 month ]
Same as current
Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
Evaluation of the Methods and Management of Acute Coronary Events-4: Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.

Over the last few years the chance of dying from a heart attack in England and Wales has reduced dramatically. Even so, there remain huge differences in mortality between hospitals. For example, up to a third of patients with a heart attack who attend hospitals in England are more likely to die than would be expected. That is, the type of treatment and the risk of death depend upon where a patient lives and which hospital they attend. In part, the variation in death may be due to the services available at the hospital or to factors such as socioeconomic deprivation. It may also relate to other factors such as depression, cardiac rehabilitation, patient experience of hospital care and whether patients take their medication after discharge from hospital.

Notably, the challenges posed by poor drug adherence to secondary prevention medications are recognised by the World Health Organisation as the highest area of priority for improving individual health throughout the world. In addition, Patient Reported Outcome Measures (PROMs) are set to be the cornerstone of the evaluation of patient experiences of National Health Service quality of care.

Using statistical approaches that include measures of quality of life, we propose to examine data about heart attacks in England and investigate the 'postcode lottery of care'. Our aim, using regional data about heart attacks is to identify and measure the effects of hospital care. This research will identify hospital qualities that promote improved patient care. In doing so, best practice will be highlighted and healthcare policy changed so that all patients will have an equal chance of surviving a heart attack.

Observational [Patient Registry]
Observational Model: Cohort
Time Perspective: Prospective
12 Months
Retention:   Samples With DNA
Blood, Urine
Non-Probability Sample
A total of 5555 consented patients were recruited from acute Trusts in England.
Acute Myocardial Infarction
Not Provided
Acute myocardial infarction
Drug Adherence
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
March 2013
February 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

Age > 18 years, both sexes, acute admission to the acute Trust with suspected acute coronary syndrome (ACS).

Exclusion Criteria:

Patients at a terminal stage of any illness, and those in whom follow up would be inappropriate or impractical.

Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Not Provided
Oras Alabas, University of Leeds
University of Leeds
Not Provided
Principal Investigator: Chris P Gale, PhD University of Leeds
University of Leeds
April 2013