Does Cold Provocation Increase Brown Adipose Tissue Volume?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01797328
Recruitment Status : Completed
First Posted : February 22, 2013
Results First Posted : April 25, 2017
Last Update Posted : April 25, 2017
Information provided by (Responsible Party):
Fredrik H Nystrom, University Hospital, Linkoeping

February 18, 2013
February 22, 2013
October 26, 2016
April 25, 2017
April 25, 2017
February 2013
May 2015   (Final data collection date for primary outcome measure)
Brown Adipose Tissue, Absolute Volume [ Time Frame: Baseline and 6 week ]
Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)
brown adipose tissue volume [ Time Frame: 6 weeks ]
Complete list of historical versions of study NCT01797328 on Archive Site
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changes in metabolic rate [ Time Frame: 6 weeks ]
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Does Cold Provocation Increase Brown Adipose Tissue Volume?
Study of the Effects of Temperature on Amount of Brown Adipose Tissue in Humans
About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.
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Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Brown Adipose Tissue, Human
  • Procedure: cold arm
    1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering
  • Procedure: warm arm
    To the best of ability avoid feeling cold during 6 weeks
  • Active Comparator: cold provocation
    cold arm
    Intervention: Procedure: cold arm
  • Active Comparator: to avoid feeling cold
    warm arm
    Intervention: Procedure: warm arm
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
June 2015
May 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria: healthy subjects -

Exclusion Criteria: any significant disease, ot other conditions that interferes with magnetic resonance imaging

Sexes Eligible for Study: All
18 Years to 50 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
Dnr2013/41-32 ( Other Identifier: Linkoping review board, Sweden )
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Fredrik H Nystrom, University Hospital, Linkoeping
University Hospital, Linkoeping
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Not Provided
University Hospital, Linkoeping
April 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP