Tailored Intervention to Improve Medication Adherence in Patients With Hypertension

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01742923
Recruitment Status : Completed
First Posted : December 6, 2012
Last Update Posted : November 18, 2015
University of Southern Denmark
Information provided by (Responsible Party):
Ulla Hedegaard, Odense University Hospital

December 4, 2012
December 6, 2012
November 18, 2015
December 2012
August 2014   (Final data collection date for primary outcome measure)
Percent of patients that are at least 80% adherent (Medication possession rate > 0.8) to antihypertensives and statins [ Time Frame: One year from inclusion ]
Same as current
Complete list of historical versions of study NCT01742923 on Archive Site
  • Non-persistence with antihypertensives and statins measured by percent of patients that are not supplied with medications for more than three continuous months [ Time Frame: One year from inclusion ]
  • Reduction in systolic and diastolic blood pressure [ Time Frame: One year from inclusion ]
  • Composite endpoint (stroke, myocardial infarction or cardiovascular death) [ Time Frame: One year from inclusion ]
Same as current
Not Provided
Not Provided
Tailored Intervention to Improve Medication Adherence in Patients With Hypertension
Pharmacist Intervention Programme in Secondary Care to Improve Medication Adherence in Patients With Hypertension
Patients with hypertension have an increased risk of stroke and myocardial infarction. However, poor adherence to treatment with antihypertensives and lipid-lowering agents occurs frequently within this patient group. The purpose of this study is to investigate whether a complex tailored intervention in a hospital setting will lead to increased medication adherence and fewer cardiovascular events when compared to a usual care group. Interventions focus on motivational interviewing, medication review and telephone follow up.
Not Provided
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
  • Behavioral: Complex tailored intervention
  • Behavioral: Usual care
  • Placebo Comparator: Usual care
    Usual care
    Intervention: Behavioral: Usual care
  • Experimental: Complex tailored intervention

    The interventions consists of 3 elements:

    1. Medication review with recommendations focused on antihypertensives and statins and adherence to guidelines and patient´s adherence to medications
    2. Consultation with a pharmacist using motivational interviewing techniques
    3. Follow-up telephone calls one month and six months after inclusion
    Intervention: Behavioral: Complex tailored intervention

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
September 2014
August 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

Age: 18 years or older

  • Patients receiving ambulatory treatment for hypertension in a hospital setting
  • The patient or a carer usually dispenses the patient's medications
  • Patient lives in the Southern Region of Denmark
  • Written consent

Exclusion Criteria:

  • Lives in a care home or institution
  • Receive dose dispensed medicine from a pharmacy
  • Medicine is dispensed by a nurse in the patient's home
  • Correctional mental health patients
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Ulla Hedegaard, Odense University Hospital
Odense University Hospital
University of Southern Denmark
Not Provided
Odense University Hospital
November 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP