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Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2012 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01718405
First Posted: October 31, 2012
Last Update Posted: October 31, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Hillel Yaffe Medical Center
October 10, 2012
October 31, 2012
October 31, 2012
November 2012
November 2015   (Final data collection date for primary outcome measure)
Cognitive Functioning After Exercise [ Time Frame: Five minutes ]
Computerized battery of tests evaluating cognitive functioning
Same as current
No Changes Posted
Not Provided
Not Provided
Genetic Variation Associated with Different Cognitive Functioning [ Time Frame: Two years ]
Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.
Same as current
 
Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function
Not Provided
Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.
Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Primary Purpose: Basic Science
Executive Function
  • Other: Cognitive function after exercise test
    The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.
  • Genetic: Blood sample analysis
    In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control. Cognitive function will be tested before and after each session.
Interventions:
  • Other: Cognitive function after exercise test
  • Genetic: Blood sample analysis
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
150
November 2017
November 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Physical Education Students
  • Able to sign consent form

Exclusion Criteria:

  • Competitive athletes
  • Smokers
  • Neurologic or psychologic orders
  • Chronic diseases
  • Head Injuries
  • Hospitalization in the previous 3 months
  • Pregnant
Sexes Eligible for Study: All
20 Years to 35 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT01718405
0049
Yes
Not Provided
Not Provided
Hillel Yaffe Medical Center
Hillel Yaffe Medical Center
Not Provided
Not Provided
Hillel Yaffe Medical Center
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP