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Beetroot Enriched Bread, Blood Pressure and Vascular Function

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01706718
First Posted: October 15, 2012
Last Update Posted: October 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Julie Lovegrove, University of Reading
September 27, 2012
October 15, 2012
October 12, 2017
June 2010
October 2010   (Final data collection date for primary outcome measure)
Vascular reactivity [ Time Frame: Change from baseline at 2, 4 and 6 hours after bread consumption ]
Forearm blood flow by Laser Doppler Imaging with iontophoresis
Same as current
No Changes Posted
  • Arterial stiffness [ Time Frame: Change from baseline at 2, 4 and 6 hours after bread consumption ]
    Pulse wave analysis (PWA) and velocity (PWV)
  • Blood pressure [ Time Frame: Change from baseline at 30 minute intervals for 7 hours ]
    By ambulatory blood pressure monitor
  • Plasma nitrate [ Time Frame: Every 30 minutes for 7 hours ]
  • Plasma nitrite [ Time Frame: Every 30 minutes for 7 hours ]
Same as current
Not Provided
Not Provided
 
Beetroot Enriched Bread, Blood Pressure and Vascular Function
The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men
Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Prevention
Hypertension
Dietary Supplement: Bread
  • Placebo Comparator: Control white bread
    Intervention: Dietary Supplement: Bread
  • Experimental: Beetroot bread
    Intervention: Dietary Supplement: Bread

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
24
October 2010
October 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male
  • A signed consent form
  • Age 18-64 years
  • Body mass index - 18.5-30 kg/m2
  • Non-smoking, healthy individuals
  • Normal blood pressure at screening (< 150/90)

Exclusion Criteria:

  • Subjects with anaemia
  • Sufferers of chronic illnesses
  • Individuals with food allergies
  • People with diabetes
  • People with coeliac disease
  • Women
  • Vegetarians
Sexes Eligible for Study: Male
18 Years to 64 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01706718
10/18
University of Reading ( Other Identifier: University of Reading )
Yes
Not Provided
Not Provided
Julie Lovegrove, University of Reading
University of Reading
Not Provided
Not Provided
University of Reading
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP