Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
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ClinicalTrials.gov Identifier: NCT01698853 |
Recruitment Status
: Unknown
Verified September 2012 by Xijing Hospital.
Recruitment status was: Not yet recruiting
First Posted
: October 3, 2012
Last Update Posted
: October 3, 2012
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Tracking Information | ||||
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First Submitted Date | September 25, 2012 | |||
First Posted Date | October 3, 2012 | |||
Last Update Posted Date | October 3, 2012 | |||
Study Start Date | October 2012 | |||
Estimated Primary Completion Date | March 2013 (Final data collection date for primary outcome measure) | |||
Current Primary Outcome Measures |
The difference between peripheral arterial oxygenation and aortic root blood oxygenation [ Time Frame: patients will be followed up during the cardiopulmonary bypass. Blood samples will be collected at 3 timepoints which is specified in the DESCRIPTION ] The three time points for blood sample collection are:1.right before clamping the aorta; 2.Three minutes after **** without ventilation;3.5 min after re-initiate mechanical ventilation.
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Original Primary Outcome Measures | Same as current | |||
Change History | No Changes Posted | |||
Current Secondary Outcome Measures | Not Provided | |||
Original Secondary Outcome Measures | Not Provided | |||
Current Other Outcome Measures | Not Provided | |||
Original Other Outcome Measures | Not Provided | |||
Descriptive Information | ||||
Brief Title | Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy | |||
Official Title | The Difference Between Central and Peripheral Arterial Blood Oxygen Saturation in Patients Undergoing Cardiac Surgery With Different Cardiopulmonary Bypass Strategy | |||
Brief Summary | Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion. Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied. The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated. |
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Detailed Description | All patients included will be assigned into two different groups according to the surgical approach,one group is named "NP" with normal perfusion,and the other is named "RP" with retrograde perfusion. For all the patients,we will obtain 0.5ml blood from both peripheral arterial and aortic root for blood gas analysis at some specific time points. We will focus on the differences of arterial oxygenation between peripheral arterial and aortic root at each group.At the same time,we will analyse the impact of artificial ventilation on it. |
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Study Type | Observational | |||
Study Design | Time Perspective: Prospective | |||
Target Follow-Up Duration | Not Provided | |||
Biospecimen | Not Provided | |||
Sampling Method | Non-Probability Sample | |||
Study Population | patient undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass | |||
Condition |
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Intervention | Not Provided | |||
Study Groups/Cohorts | Not Provided | |||
Publications * | Not Provided | |||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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Recruitment Information | ||||
Recruitment Status | Unknown status | |||
Estimated Enrollment |
60 | |||
Original Estimated Enrollment | Same as current | |||
Estimated Study Completion Date | May 2013 | |||
Estimated Primary Completion Date | March 2013 (Final data collection date for primary outcome measure) | |||
Eligibility Criteria | Inclusion Criteria:
Exclusion Criteria:
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Sex/Gender |
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Ages | 18 Years and older (Adult, Senior) | |||
Accepts Healthy Volunteers | No | |||
Contacts | Contact information is only displayed when the study is recruiting subjects | |||
Listed Location Countries | China | |||
Removed Location Countries | ||||
Administrative Information | ||||
NCT Number | NCT01698853 | |||
Other Study ID Numbers | 192837 | |||
Has Data Monitoring Committee | No | |||
U.S. FDA-regulated Product | Not Provided | |||
IPD Sharing Statement | Not Provided | |||
Responsible Party | Xijing Hospital | |||
Study Sponsor | Xijing Hospital | |||
Collaborators | Not Provided | |||
Investigators |
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PRS Account | Xijing Hospital | |||
Verification Date | September 2012 |