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Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

This study is currently recruiting participants.
Verified November 2016 by University Hospital Inselspital, Berne
Sponsor:
ClinicalTrials.gov Identifier:
NCT01690039
First Posted: September 21, 2012
Last Update Posted: November 28, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital Inselspital, Berne
September 10, 2012
September 21, 2012
November 28, 2016
September 2012
September 2017   (Final data collection date for primary outcome measure)
Capability of urinary acidification [ Time Frame: Five to six hours ]
Same as current
Complete list of historical versions of study NCT01690039 on ClinicalTrials.gov Archive Site
Polymorphisms in the ATP6V1 gene [ Time Frame: 12 months ]
Same as current
Not Provided
Not Provided
 
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers

Purpose

  1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.
  2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.
Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Blood
Non-Probability Sample
Patients suffered from at least one kidney stone episode.
  • Acidosis, Renal Tubular
  • Nephrolithiasis
  • Vacuolar Proton-Translocating ATPases
Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.
Other Name: Application of Furosemide (Lasix® ) and Fludrocortisone (Florinef®)
All study participants
Furosemide-Fludrocortisone-Test and Ammonium chloride-Loading Test will be performed in renal stone patients.
Intervention: Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
200
September 2017
September 2017   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • One or more episodes of nephrolithiasis

Exclusion Criteria:

  • Absence of informed consent
  • All conditions affecting renal acidification
  • Pregnancy
  • Nursing
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Yes
Contact: Daniel Fuster, Attending physician Nephrology ++41 (0)31 631 37 49 daniel.fuster@ibmm.unibe.ch
Contact: Nasser Dhayat, Resident Nephrology ++41 (0)31 632 31 44 nasser.dhayat@insel.ch
Switzerland
 
 
NCT01690039
090/12
No
Not Provided
Not Provided
University Hospital Inselspital, Berne
University Hospital Inselspital, Berne
Not Provided
Principal Investigator: Daniel Fuster, Attending physician Nephrology Department of Nephrology and Hypertension, Bern University Hospital
University Hospital Inselspital, Berne
November 2016