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Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01686984
First Posted: September 18, 2012
Last Update Posted: May 14, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Region Skane
September 13, 2012
September 18, 2012
May 14, 2015
September 2012
May 2015   (Final data collection date for primary outcome measure)
Carbon dioxide elimination in a ventilator assisted breath. [ Time Frame: 30 minutes ]
Same as current
Complete list of historical versions of study NCT01686984 on ClinicalTrials.gov Archive Site
Blood CO2 concentration. [ Time Frame: 30 minutes ]
Same as current
Not Provided
Not Provided
 
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.

Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
  • Pulmonary Gas Exchange
  • Carbon Dioxide
Other: Altered breath
Experimental: Altered breath
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Intervention: Other: Altered breath
Sturesson LW, Malmkvist G, Allvin S, Collryd M, Bodelsson M, Jonson B. An appropriate inspiratory flow pattern can enhance CO2 exchange, facilitating protective ventilation of healthy lungs. Br J Anaesth. 2016 Aug;117(2):243-9. doi: 10.1093/bja/aew194.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
8
May 2015
May 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • No known primary lung disease

Exclusion Criteria:

  • Primary lung disease
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Sweden
 
 
NCT01686984
2012/381
No
Not Provided
Not Provided
Region Skane
Region Skane
Not Provided
Principal Investigator: Mikael Bodelsson, Professor Division of Anesthesia, Skane University Hospital, Lund, Sweden
Region Skane
May 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP
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