Grass Sensitisation and Allergic Rhinitis in Thai Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01686022
Recruitment Status : Completed
First Posted : September 17, 2012
Last Update Posted : September 14, 2016
National Research Council of Thailand
Information provided by (Responsible Party):
Punchama Pacharn, Mahidol University

September 12, 2012
September 17, 2012
September 14, 2016
October 2012
October 2015   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01686022 on Archive Site
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Grass Sensitisation and Allergic Rhinitis in Thai Patients
The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients
Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

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Retention:   Samples Without DNA
Non-Probability Sample
Allergy Clinic
  • Allergy to Grass Pollen
  • Allergic Rhinitis Due to Weed Pollens
Other: Immunoblot
serum specific IgE binds to grass extract by immunoblot
Pollen Allergy
Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition
Intervention: Other: Immunoblot
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
October 2015
October 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Allergic rhinitis patients age 10-50 years old
  • Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

  • Chronic illness such as cardiovascular diseases, liver diseases
  • History of anaphylaxis
  • Pregnancy
Sexes Eligible for Study: All
10 Years to 50 Years   (Child, Adult)
Contact information is only displayed when the study is recruiting subjects
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Plan to Share IPD: Undecided
Punchama Pacharn, Mahidol University
Mahidol University
National Research Council of Thailand
Principal Investigator: Punchama Pacharn, MD Mahidol University
Mahidol University
September 2016