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Obesity-related Genes in Taiwanese Undergoing Weight Loss

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ClinicalTrials.gov Identifier: NCT01684280
Recruitment Status : Completed
First Posted : September 12, 2012
Last Update Posted : September 13, 2012
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by (Responsible Party):
Sung Ling Yeh, Taipei Medical University Hospital

Tracking Information
First Submitted Date September 10, 2012
First Posted Date September 12, 2012
Last Update Posted Date September 13, 2012
Study Start Date June 2010
Actual Primary Completion Date September 2010   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: September 11, 2012)
MicroRNA expression in abdominal omental adipose tissues [ Time Frame: up to 28 weeks ]
MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity
Original Primary Outcome Measures
 (submitted: September 10, 2012)
MicroRNA expression in abdominal omental adipose tissues [ Time Frame: 2010/03-2010/09 ]
MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity
Change History Complete list of historical versions of study NCT01684280 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Obesity-related Genes in Taiwanese Undergoing Weight Loss
Official Title Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss
Brief Summary

To investigate:

  1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.
  2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.
Detailed Description Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.
Study Type Observational
Study Design Observational Model: Case Control
Time Perspective: Cross-Sectional
Target Follow-Up Duration Not Provided
Biospecimen Retention:   None Retained
Description:
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent laparoscopic bariatric surgery.
Sampling Method Probability Sample
Study Population Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men (n = 9) and women (n =10) who underwent bariatric surgery. Their BMI were all over 40 kg/ m2, and ages between 19-63 years.
Condition Morbid Obesity
Intervention Genetic: gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Other Name: BMI were all over 40 kg/ m2
Study Groups/Cohorts gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Intervention: Genetic: gender
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: September 10, 2012)
20
Original Actual Enrollment Same as current
Actual Study Completion Date September 2010
Actual Primary Completion Date September 2010   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Morbid obesity,BMIs> 40 kg/m2
  • Subjects who underwent bariatric surgery

Exclusion Criteria:

  • Obese subjects with complicated metabolic disorders
  • Thyroid disease
Sex/Gender
Sexes Eligible for Study: All
Ages 19 Years to 63 Years   (Adult)
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Taiwan
Removed Location Countries  
 
Administrative Information
NCT Number NCT01684280
Other Study ID Numbers CRC-06-09-10
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Sung Ling Yeh, Taipei Medical University Hospital
Study Sponsor Sung Ling Yeh
Collaborators National Science Council, Taiwan
Investigators
Study Director: Wang Weu Comprehensive Weight Management Center Taipei Medical University Hospital
PRS Account Taipei Medical University Hospital
Verification Date September 2012