We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications (MIRPROT)

This study has been terminated.
(Insufficient microRNA for the analysis)
Sponsor:
ClinicalTrials.gov Identifier:
NCT01681407
First Posted: September 10, 2012
Last Update Posted: June 19, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Amichai Hareven, HaEmek Medical Center, Israel
September 5, 2012
September 10, 2012
June 19, 2015
November 2011
July 2013   (Final data collection date for primary outcome measure)
Depressive symptoms remission or response rates, under usual SSRI treatment. [ Time Frame: 10 weeks of follow up ]
Not Provided
Complete list of historical versions of study NCT01681407 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications
Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications.

A pilot study of mapping the peripheral plasma micro-RNA and proteomics patterns in depressive patients, treated with SSRI medications. It is an observational clinical bio-markers laboratory controlled research with no device.

The research includes two groups; one for patients diagnosed of having depression, and will get a standard SSRI medication regimen. Second group is for control subjects without depression. An option for a third group is planned to include first degree relatives of the depressed patients. After giving their informed consents, subjects and patients will go through standard clinical psychiatric interview, and routine clinical lab tests. Clinical standard, specific depression and anxiety questionnaires will be held at four follow-up meetings: at start; after 2 weeks; 4 weeks; and 10 weeks. Subjects and patients will be asked to give blood samples at these points of time for the lab processing: Complete plasma proteomics and specific micro-RNA levels.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Subjects and patients will be asked to give blood samples at 4 points of time for the lab processing: micro-RNA and proteome profiling/
Non-Probability Sample
Patients at community or hospital settings. Patients were clinically evaluated for suspected depression.
Depression
Not Provided
  • Depressed Patients
    Patients: Group of patients that are diagnosed for having depression, and are suitable for SSRI treatment.
  • Non-Depressed Controls
    Controls: Volunteers that had clinical screening with no depression diagnosis.
  • Patients Relatives
    Patient Relatives (Optional group for later stage): First degree relatives with no depression diagnosis.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
17
February 2014
July 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Depressed patients,over 18 yo
  • Untreated with SSRI, in the last 3 months

Exclusion Criteria:

  • Bipolar patients or another major psychopathology
  • Depressive disorder clearly due to general medical condition, or drug related
  • BMI under 18.5 or above 40
  • Pregnant patients
  • Active suicidality
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT01681407
EMC-07411-CTIL
Yes
Not Provided
Not Provided
Amichai Hareven, HaEmek Medical Center, Israel
HaEmek Medical Center, Israel
Not Provided
Not Provided
HaEmek Medical Center, Israel
June 2015