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Cancer Biology of Retinoblastoma

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ClinicalTrials.gov Identifier: NCT01642823
Recruitment Status : Terminated (Logistics)
First Posted : July 17, 2012
Last Update Posted : March 6, 2017
Sponsor:
Information provided by (Responsible Party):
Stanford University

July 11, 2012
July 17, 2012
March 6, 2017
July 2012
December 2015   (Final data collection date for primary outcome measure)
Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations [ Time Frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming ]
Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.
Same as current
Complete list of historical versions of study NCT01642823 on ClinicalTrials.gov Archive Site
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Cancer Biology of Retinoblastoma
Cancer Biology of Retinoblastoma
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
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Observational
Observational Model: Case-Only
Time Perspective: Retrospective
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Retention:   Samples With DNA
Description:
retinoblastoma tumor tissue sample
Non-Probability Sample
Retinoblastoma patients undergoing surgical removal of part or all of their tumor, with or without the remainder of the eye
Retinoblastoma
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retinablastoma tumor tissue
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
8
20
December 2015
December 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patient must have retinoblastoma
  • Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
  • Parental consent

Exclusion Criteria:

  • Diagnosis other than Retinoblastoma
  • No surgical sampling of tumor is planned as part of standard care
  • Parental preference to not participate.
Sexes Eligible for Study: All
up to 5 Years   (Child)
No
Contact information is only displayed when the study is recruiting subjects
Guatemala,   United States
 
 
NCT01642823
PEDSEYE0002
Yes
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Stanford University
Stanford University
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Principal Investigator: Julien Sage Stanford University
Stanford University
March 2017