We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov Menu

Pharmacoinvasive Therapy With Prourokinase

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: July 17, 2012
Last Update Posted: July 27, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Suzhou Landing Pharmaceuticals
July 13, 2012
July 17, 2012
July 27, 2012
November 2008
November 2009   (Final data collection date for primary outcome measure)
angiographic parameters which can demonstrate the myocardium reperfusion, including TIMI flow grade (grade I-III), TIMI frame count (frame) and myocardial blush grade (MBG,grade 0-3). [ Time Frame: 90 minutes after prourokinase bolus ]
angiographic parameters which can demonstrate the myocardium reperfusion [ Time Frame: 90 minutes after prourokinase bolus ]
Complete list of historical versions of study NCT01642667 on ClinicalTrials.gov Archive Site
major adverse cardiac events [MACE, defined as the composite of all cause-death, reinfarction, revascularization (including target vessel and non-target vessel revascularizations), or rehospitalization due to new or worsening congestive heart failure] [ Time Frame: 12 month after enrollment ]
Same as current
Not Provided
Not Provided
Pharmacoinvasive Therapy With Prourokinase
The Efficacy and Safety of Pharmacoinvasive Therapy With Prourokinase for Acute ST Segment Elevation Myocardial Infarction Patients With Expected Percutaneous Coronary Intervention Related Delay
The aim of this study is to elucidate the efficacy and safety of pharmacoinvasive therapy by using prourokinase (prouk), a unique fibrin-specific agent, in patients with ST-segment elevation myocardial infarction (STEMI)
Not Provided
Phase 2
Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
ST-segment Elevation Myocardial Infarction (STEMI)
  • Drug: Prourokinase
    a bolus of 1.2 million IU and an infusion of 4.8 million IU in 60 min.
  • Drug: Placebo
  • Placebo Comparator: primary PCI
    Intervention: Drug: Placebo
  • Active Comparator: prouk-PCI
    Intervention: Drug: Prourokinase
Han YL, Liu JN, Jing QM, Ma YY, Jiang TM, Pu K, Zhao RP, Zhao X, Liu HW, Xu K, Wang G, Wang B, Sun RH, Wang J. The efficacy and safety of pharmacoinvasive therapy with prourokinase for acute ST-segment elevation myocardial infarction patients with expected long percutaneous coronary intervention-related delay. Cardiovasc Ther. 2013 Oct;31(5):285-90. doi: 10.1111/1755-5922.12020.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
December 2010
November 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • age 75 years or younger, symptom onset 6 h or less before randomization, intention to undertake primary PCI, ST-segment elevation of 2 mm or more in two anterior leads or of 1 mm or more in two inferior leads if they had ST-segment elevation, or new left bundle-branch block.

Exclusion Criteria:

  • expected arrival at the catheterization laboratory less than 1 h or more than 3 h after randomization, anticipated problems with vascular access, previous enrollment to other studies, and the usual contraindications to thrombolytic therapy.
Sexes Eligible for Study: All
up to 75 Years   (Child, Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Suzhou Landing Pharmaceuticals
Suzhou Landing Pharmaceuticals
Not Provided
Not Provided
Suzhou Landing Pharmaceuticals
July 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP