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Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome

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ClinicalTrials.gov Identifier: NCT01622751
Recruitment Status : Completed
First Posted : June 19, 2012
Last Update Posted : June 19, 2012
Sponsor:
Information provided by:
Samsung Medical Center

January 18, 2012
June 19, 2012
June 19, 2012
January 2007
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No Changes Posted
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Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome
Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome

Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing effect, and has been related to obstructive sleep apnea syndrome. In addition, children with Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of rapid eye movement (REM) sleep.

Objective: To determine if the sleep stages are related to the plasma levels of adiponectin, resistin, and RBP4 (retinol binding protein-4), and whether these relationships are influenced by age, obesity and insulin resistance.

This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center [median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)] and 18 obese healthy children [median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)].
Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample
The study population comprised 28 children with PWS and 18 controls. The enrolled children with PWS were volunteers from a pool of approximately 100 children with PWS followed up at the Samsung Medical Center. The controls were healthy children from several elementary and middle schools located in the southern areas of Seoul.
  • Prader-Willi Syndrome
  • Obesity
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
46
June 2007
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Inclusion Criteria:

  • Prader Willi syndrome healthy children

Exclusion Criteria:

  • history of seizure,
  • mental or brain illness,
  • adenoidectomy,
  • tonsillectomy,
  • craniofacial anomalies and any treatment at the time of the study.
Sexes Eligible for Study: All
5 Years to 12 Years   (Child)
Yes
Contact information is only displayed when the study is recruiting subjects
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NCT01622751
2006-09-055
Yes
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Samsung Medical Center
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Principal Investigator: Dong-Kyu Jin, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine
Samsung Medical Center
June 2012