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Causes of Visual Loss in Retinal Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by Simon Taylor, Royal Surrey County Hospital.
Recruitment status was:  Enrolling by invitation
Sponsor:
Information provided by (Responsible Party):
Simon Taylor, Royal Surrey County Hospital
ClinicalTrials.gov Identifier:
NCT01613963
First received: May 29, 2012
Last updated: June 5, 2012
Last verified: June 2012
May 29, 2012
June 5, 2012
May 2012
December 2012   (Final data collection date for primary outcome measure)
Visual acuity at 5 years [ Time Frame: 5 years ]
Best-corrected visual acuity at 5 years
Same as current
No Changes Posted
  • Visual acuity at 10 years [ Time Frame: 10 years ]
    Best corrected visual acuity at 10 years
  • Source of referral [ Time Frame: Baseline ]
    Categorised as A&E/GP referral/Optician referral/Tertiary referral
  • Laterality [ Time Frame: Baseline ]

    Categorised as:

    Right eye/Left eye/Bilateral

  • Anatomical diagnosis [ Time Frame: Baseline ]

    Cateogorised as:

    Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis

  • Aetiological diagnosis [ Time Frame: Baseline ]

    Diagnosed as:

    Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant

  • Associated systemic disease [ Time Frame: Baseline ]
    Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis
  • Complications of disease and causes of visual loss at 5 years [ Time Frame: 5 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Complications of disease and causes of visual loss at 10 years [ Time Frame: 10 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Complications of disease and causes of visual loss [ Time Frame: Up to 10 years ]

    Categorised into:

    Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other

  • Treatment measures employed [ Time Frame: Up to 10 years ]

    Categorised into:

    Topical treatment / periocular steroid / intraocular steroid / intraocular other agent / Glaucoma treatment / systemic immunosuppressive agents

  • Complications of disease and treatment [ Time Frame: Up to 10 years ]

    Categorised into:

    1. Local complications: Raised intraocular pressure / cataract / endophthalmitis / other
    2. Systemic complications: Diabetes / hypertension / cholesterol / liver function / bone density loss / other
  • Surgical procedures [ Time Frame: Up to 10 years ]
    List and dates of any intraocular surgery performed during the study
  • Burden of disease - appointments [ Time Frame: Up to 10 years ]
    Number of outpatient appointments over the course of the study
  • Burden of disease - outpatient procedures [ Time Frame: Up to 10 years ]
    Number of outpatient procedures over the course of the study
  • Burden of disease - inpatient procedures [ Time Frame: Up to 10 years ]
    Number of inpatient procedures over the course of the study
  • Blind registration [ Time Frame: Up to 10 years ]
    Year of any registration as partially sighted or blind
Same as current
Not Provided
Not Provided
 
Causes of Visual Loss in Retinal Disease
Observational Study of Visual Outcomes in Retinal Disease
This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.
This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.
Observational
Observational Model: Cohort
Time Perspective: Retrospective
Not Provided
Not Provided
Non-Probability Sample
Patients with ocular inflammation
  • Uveitis
  • Scleritis
Drug: Immunosuppressive Agents
Treatment with systemic corticosteroids and/or immunosuppressive agents Treatment with local corticosteroids and other drugs
Other Names:
  • Prednisolone
  • Azathioprine
  • Methotrexate
  • Mycophenolate mofetil
  • Cyclosporine A
  • Infliximab
  • Adalimumab
  • Etanercept
  • Rituximab
Patients with ocular inflammation
Patients with ocular inflammation
Intervention: Drug: Immunosuppressive Agents
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
2000
December 2012
December 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • patients with a diagnosis of ocular inflammation
  • patients with at least 6 months of follow-up

Exclusion Criteria:

  • patients without a diagnosis of ocular inflammation
  • patients with less than 6 months of follow-up
Sexes Eligible for Study: All
16 Years and older   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01613963
12DEV0010
No
Not Provided
Not Provided
Simon Taylor, Royal Surrey County Hospital
Royal Surrey County Hospital
Not Provided
Principal Investigator: Simon RJ Taylor, PhD FRCOphth Royal Surrey County Hospital
Royal Surrey County Hospital
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP