Preoperative Vitamin D for Post-thyroidectomy Hypocalcemia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2012 by University of Alberta.
Recruitment status was  Not yet recruiting
Information provided by (Responsible Party):
Caroline Xu, University of Alberta Identifier:
First received: May 24, 2012
Last updated: May 29, 2012
Last verified: May 2012

May 24, 2012
May 29, 2012
August 2012
August 2013   (final data collection date for primary outcome measure)
Hypocalcemia [ Time Frame: Transient (<72 hrs post-operatively) ] [ Designated as safety issue: No ]
Clinical signs and symptoms(paraesthesias, etc.) OR Laboratory evidence (ICa < 0.9) Need for IV calcium supplementation
Same as current
No Changes Posted
Hypocalcemia [ Time Frame: Permanent (>4 weeks) ] [ Designated as safety issue: No ]
ICa at 6 weeks and need for continued supplementation beyond 6 weeks post-op (i.e. 3 months follow-up post-operatively)
Same as current
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Preoperative Vitamin D for Post-thyroidectomy Hypocalcemia
Pre-operative Vitamin D Supplementation to Reduce Post-operative Hypocalcemia in Patients Undergoing Total Thyroidectomy: A Randomized Controlled Trial
The purpose of this study is to determine if pre-operative vitamin D supplementation lowers the incidence of post-operative transient or permanent hypoparathyroidism in patients undergoing total thyroidectomy.
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Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Drug: Vitamin D
    Vitamin D 800 units for 4 weeks preoperatively
  • Drug: Placebo
  • Placebo Comparator: Placebo
    Intervention: Drug: Placebo
  • Experimental: Treatment
    Pre-operative Vitamin D 800 units x 4 weeks
    Intervention: Drug: Vitamin D
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Not yet recruiting
December 2013
August 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients undergoing total thyroidecomty +/- CND
  • Adult (age > or = 18)

Exclusion Criteria:

  • Known chronic kidney disease
  • Known primary hyper or hypoparathyroidism
  • Known hypoalbuminemia
  • Concurrent use medications affecting calcium metabolism
  • Completion hemithyroidectomy
18 Years and older   (Adult, Senior)
Contact: Caroline C Xu, MD 7809694655
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Not Provided
Caroline Xu, University of Alberta
University of Alberta
Not Provided
Not Provided
University of Alberta
May 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP