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Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes

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ClinicalTrials.gov Identifier: NCT01593956
Recruitment Status : Unknown
Verified May 2013 by Jonathan List, Charite University, Berlin, Germany.
Recruitment status was:  Recruiting
First Posted : May 8, 2012
Last Update Posted : May 23, 2013
Sponsor:
Information provided by (Responsible Party):
Jonathan List, Charite University, Berlin, Germany

Tracking Information
First Submitted Date  ICMJE May 7, 2012
First Posted Date  ICMJE May 8, 2012
Last Update Posted Date May 23, 2013
Study Start Date  ICMJE March 2012
Estimated Primary Completion Date July 2013   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: May 7, 2012)
Improvement of cortical plasticity after anodal tDCS in concussed athletes
Original Primary Outcome Measures  ICMJE Same as current
Change History
Current Secondary Outcome Measures  ICMJE Not Provided
Original Secondary Outcome Measures  ICMJE Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
Official Title  ICMJE Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers
Brief Summary

Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS.

GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.

Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.

Detailed Description Not Provided
Study Type  ICMJE Interventional
Study Phase  ICMJE Not Applicable
Study Design  ICMJE Primary Purpose: Treatment
Condition  ICMJE
  • Concussed Athletes
  • Healthy Controls
Intervention  ICMJE Behavioral: tDCS
Study Arms  ICMJE
  • Concussed athletes
    Intervention: Behavioral: tDCS
  • Healthy controls
    Intervention: Behavioral: tDCS
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Unknown status
Estimated Enrollment  ICMJE
 (submitted: May 7, 2012)
30
Original Estimated Enrollment  ICMJE Same as current
Study Completion Date  ICMJE Not Provided
Estimated Primary Completion Date July 2013   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • history of at least 2 sports concussion
  • age 18 - 50 years

Exclusion Criteria:

  • structural deficit on cerebral MRI
  • Epilepsy
  • neurological disorder
  • intake of CNS-active drugs
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 50 Years   (Adult)
Accepts Healthy Volunteers  ICMJE Yes
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE Germany
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT01593956
Other Study ID Numbers  ICMJE EA1/021/12
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Jonathan List, Charite University, Berlin, Germany
Study Sponsor  ICMJE Charite University, Berlin, Germany
Collaborators  ICMJE Not Provided
Investigators  ICMJE
Principal Investigator: Jonathan List, MD Charité - Department of Neurology
Principal Investigator: Agnes Flöel, Prof. Charité - Department of Neurology
PRS Account Charite University, Berlin, Germany
Verification Date May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP