We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

The Influence of Amitriptyline on Learning in a Visual Discrimination Task

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01566825
Recruitment Status : Completed
First Posted : March 29, 2012
Last Update Posted : March 29, 2012
Information provided by (Responsible Party):

March 27, 2012
March 29, 2012
March 29, 2012
August 2008
May 2009   (Final data collection date for primary outcome measure)
changes in the visual discrimination task's perception threshold [ Time Frame: The visual discrimination task's perception treshold is assessed before sleep (day 10 at 6 pm) and after sleep (day 11 at 6 pm). ]
Improvement in this task is defined as a decrease in the perception threshold between training and retrieval testing.
Same as current
No Changes Posted
amount of rapid eye movement (REM) sleep (sleep period time percentage) [ Time Frame: night from day 10 to day 11 ]
Same as current
Not Provided
Not Provided
The Influence of Amitriptyline on Learning in a Visual Discrimination Task
The Influence of Amitriptyline (Amitriptylin-CT 25 mg®) on Learning in a Visual Discrimination Task (Karni-Sagi-paradigm)
The purpose of this study is to determine whether 75 mg amitriptyline affect the sleep dependent consolidation of procedural memory (visual discrimination task, Karni-Sagi-paradigm).
Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important to determine whether antidepressive therapy can lead to amnestic impairment. We thus investigate the effects of the anticholinergic antidepressant amitriptyline on sleep-dependent memory consolidation in 32 healthy men in a double-blind, placebo-controlled, randomized parallel-group study.
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Healthy Subjects
  • Drug: Amitriptyline
    amitriptyline 25 mg at 9:30 pm, day 10, and 50 mg at 1:30 am, day 11
    Other Name: Saroten
  • Drug: Placebo
    placebo(white 8 mm Lichtenstein®) at 9:30 pm, day 10, and at 1:30 am, day 11
  • Active Comparator: Amitriptyline
    Intervention: Drug: Amitriptyline
  • Placebo Comparator: white 8 mm Lichtenstein®
    Intervention: Drug: Placebo
Goerke M, Cohrs S, Rodenbeck A, Kunz D. Differential effect of an anticholinergic antidepressant on sleep-dependent memory consolidation. Sleep. 2014 May 1;37(5):977-85. doi: 10.5665/sleep.3674.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
May 2009
May 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • male gender
  • age 18 through 40 years
  • ability to communicate effectively in German

Exclusion Criteria:

  • shift work within the past 24 months
  • any sleep disorder as measured by the Pittsburgh Sleep Quality Index
  • irregular sleep/wake patterns or extreme chronotype as measured by the Morningness-Eveningness Questionnaire
  • history of any neurologic or psychiatric disorders
  • regular medication intake within the past four weeks
  • contraindications for amitriptyline
  • abnormal electrocardiogram (ECG)
Sexes Eligible for Study: Male
18 Years to 40 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Dieter Kunz, MD, Charite University, Berlin, Germany
Dieter Kunz, MD
Not Provided
Study Chair: Dieter Kunz, MD Charite University, Berlin, Germany
Principal Investigator: Dieter Kunz, MD Charite University, Berlin, Germany
Charite University, Berlin, Germany
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP