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Change in Brain Metabolism and Cognitive Function by Aripiprazole

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01562808
First Posted: March 26, 2012
Last Update Posted: March 26, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jun Soo Kwon, Seoul National University Hospital
March 22, 2012
March 26, 2012
March 26, 2012
January 2009
May 2010   (Final data collection date for primary outcome measure)
Reaction time of correct response in N-back task [ Time Frame: 48 hrs after the administration of aripiprazole ]
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Change in Brain Metabolism and Cognitive Function by Aripiprazole
The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.

Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
  • Antipsychotics
  • Cognition
  • Brain Metabolism
  • Dopamine Receptor Occupancy
Drug: Aripiprazole
single oral administration of aripiprazole
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
15
January 2012
May 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy volunteers
  • right-handed

Exclusion Criteria:

  • any significant abnormality on routine lab
  • any psychiatric disease
Sexes Eligible for Study: Male
19 Years to 30 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
 
NCT01562808
A070001
No
Not Provided
Not Provided
Jun Soo Kwon, Seoul National University Hospital
Seoul National University Hospital
Not Provided
Principal Investigator: Jun Soo Kwon, M.D., Ph.D. Seoul National University Hospital
Seoul National University Hospital
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP