A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis
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|ClinicalTrials.gov Identifier: NCT01533480|
Recruitment Status : Completed
First Posted : February 15, 2012
Last Update Posted : February 28, 2018
|First Submitted Date ICMJE||January 31, 2012|
|First Posted Date ICMJE||February 15, 2012|
|Last Update Posted Date||February 28, 2018|
|Study Start Date ICMJE||January 2012|
|Actual Primary Completion Date||December 2014 (Final data collection date for primary outcome measure)|
|Current Primary Outcome Measures ICMJE
||Time to Viral Eradication [ Time Frame: 14 days ]
Time to viral eradication from the ocular surface, as determined by quantitative viral isolation in A549 cell tissue culture (performed on Day 0, 2, 4, 6, 8, 10, and 14)
|Original Primary Outcome Measures ICMJE||Same as current|
|Change History||Complete list of historical versions of study NCT01533480 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE||Same as current|
|Current Other Pre-specified Outcome Measures||Not Provided|
|Original Other Pre-specified Outcome Measures||Not Provided|
|Brief Title ICMJE||A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis|
|Official Title ICMJE||A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Adenovirus Conjunctivitis|
The investigators are conducting this study because the patient have an eye infection which is called adenoviral conjunctivitis, and is the most common cause of "pink eye". There is currently no treatment for this condition. However, the researchers associated with this study want to understand if using a product called Zirgan, which is a topical ointment that is already FDA-approved for other types of eye infections, will help with the type of infection that the patient currently have. Zirgan is not FDA-approved to treat your type of eye infection. Your participation in this study is expected to last 21 days but the patient will only apply the topical ointment for 14 of those days. During the study, the patient will be asked to come into this clinic 8 times.
The purpose of this study is to determine whether topical Zirgan can reduce days that the patient suffers from the eye infection, and also to see if it can prevent the infection from spreading to your second eye and to also see if it can prevent the spreading of the infection to people that the patient come in close contact with.
Zirgan will be compared to Genteal Gel in this trial. Genteal Gel is a non-prescription eye lubricant gel and is commonly used for treatment of dry eye.
The patient will be asked to apply a topical ointment (either Zirgan or Genteal gel 5 times a day for the first 7 days and then 3 times a day for the following 7 days. The patient will be asked to return to the clinic 21 days after the patient starts the study for a final check-up.
It is planned that about 80 people with Adenovirus Conjunctivitis will be enrolled in this study between 8-12 sites across the United States.
The patient will be assigned to either Zirgan or Genteal gel by chance which is similar to flipping a coin.
The study groups will be assigned in a 1:1 ratio. Neither the patient nor the study doctor or study staff will be able to pick which study group The patient is in. The patient will not know and the study doctor or study staff will not know which study group the patient is in. The study doctor or study staff can find out if it is necessary to know for your health. If this happens, the study doctor or study staff may not be able to tell the patient which study group the patient was in until everyone finishes the study.
Study Objectives To evaluate the safety and efficacy of 0.15% ganciclovir gel (Zirgan®) in patients with adenoviral keratoconjunctivitis in comparison with 0.3% hypromellose gel (Genteal gel®) as placebo.
Background Adenoviruses are the most common cause of ocular viral infection worldwide. Conjunctivitis and keratoconjunctivitis caused by adenoviruses are highly contagious. Adenovirus is a non-enveloped, double-stranded DNA virus comprised of 53 serotypes. Unlike many enveloped viruses which can be more easily inactivated, adenoviruses are resilient to disinfection and are long lasting on fomites. The ocular infection generally begins unilaterally and, in many cases, spreads to both eyes. It may cause epidemics and endemics, being most commonly spread in the summer or winter. Epidemics are common in day care centers, schools and the military and have been spread in the offices of eye care professionals. Patients may have painful conjunctival membranes and palpable preauricular adenopathy. Subsequent subepithelial corneal infiltrates can cause light sensitivity, reduced vision and lead to irregular astigmatism. The differential diagnosis includes herpes simplex, Chlamydia and enteroviral infection.
There are 3 major presentations of ocular adenovirus infection: Follicular conjunctivitis (predominantly serotypes 3, 4,7a); epidemic keratoconjunctivitis (EKC; predominantly serotypes 8, 19, 37, 53); and pharyngealconjunctival fever (mostly serotypes 3, 4, 7a, 11).
There is supporting laboratory and clinical data to warrant a clinical trial of topical ganciclovir for the treatment of adenoviral keratoconjunctivitis. Several studies has shown that ganciclovir (GCV) is active in vitro against adenovirus.
Primary Outcome The primary outcome of the study is to determine whether topical 0.15% ganciclovir (Zirgan®) gel alone will reduce the duration of viral shedding from the ocular surface, as determined by quantitative viral isolation in A549 cell tissue culture, compared to placebo 0.3% hypromellose gel (Genteal gel®).
Secondary Outcomes The secondary outcomes of the study are whether topical 0.15% ganciclovir will (1) reduce the incidence and severity of second eye involvement, (2) reduce the incidence and severity of subepithelial infiltrates, (3) reduce the secondary spread to family members, friends, classmates or co-workers (The virus is very stable at room temperature and can last for days on fomites, like towels, doorknobs, etc), (4) reduce the degree of bulbar conjunctival injection (redness of the eye, as determined by the Efron scale in the Appendix 2), (5) reduce ocular discomfort, and (6) be considered an effective treatment by the patient.
Sample Size The sample size for this study is based on the objective to demonstrate a statistically significant difference in the primary outcome measure (i.e., time to viral eradication). Approximately 350 subjects will be screened with Rapid Pathogens Screening (RPS) Adeno Detector Plus Immunoassay for adenovirus (applied to the conjunctiva of the most involved eye) to allow recruitment of approximately 80 RPS positive subjects in this study, with approximately 40 subjects per treatment group (randomization ratio of 1:1), in anticipation of approximately 40 culture positive subjects per treatment group (assuming a 100% culture positivity rate) and 38 of these culture positive subjects per treatment group completing the study (assuming a 5% dropout rate).
Thirty eight viral positive culture subjects per treatment group yields 90% power to detect a statistically significant difference in time of viral eradication between ganciclovir gel 0.15% and placebo (hypromellose gel) assuming: (1) a mean time to viral eradication of 7.0 days in the placebo group and 5.5 days in the ganciclovir group, (2) an estimated standard deviation of 2.0 days for both groups, and (3) using a two-sided α = 0.05 (two sample comparison of means).
The estimate of approximately 320 to 350 screenings to find approximately 80 RPS positive subjects was based on previous studies documenting approximately 25% prevalence of adenoviral conjunctivitis among patients with acute conjunctivitis. The estimated mean time to viral eradication of 7.0 days for the placebo was based on a placebo arm of a previous study evaluating the safety and efficacy of cidofovir in the treatment of viral epidemic keratoconjunctivitis and the estimated mean time to viral eradication of 5.5 days was based on assumed clinically significant decrease of 1.5 days compared to the placebo arm.
Virological Studies At the first study visit, the lower palpebral conjunctiva of each eye will be rubbed six to eight times using the Rapid Pathogen Screening (RPS) Adeno Detector Plus Immunoassay device. A positive result in the most involved eye is required to meet entry criteria. For patients entered and randomized into the treatment or placebo arms, further virologic studies for quantitative culture, PCR confirmation and viral serotyping using DNA sequencing will be performed,
|Study Type ICMJE||Interventional|
|Study Phase ICMJE||Phase 4|
|Study Design ICMJE||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Study Arms ICMJE||
|Publications *||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Completed|
|Actual Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Actual Study Completion Date ICMJE||April 2016|
|Actual Primary Completion Date||December 2014 (Final data collection date for primary outcome measure)|
|Eligibility Criteria ICMJE||
|Ages ICMJE||14 Years and older (Child, Adult, Older Adult)|
|Accepts Healthy Volunteers ICMJE||Yes|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries ICMJE||United States|
|Removed Location Countries|
|NCT Number ICMJE||NCT01533480|
|Other Study ID Numbers ICMJE||ADV-GAN-10-2011
pro00006720 ( Registry Identifier: Chesapeake IRB )
|Has Data Monitoring Committee||No|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement ICMJE||Not Provided|
|Responsible Party||Lifelong Vision Foundation|
|Study Sponsor ICMJE||Lifelong Vision Foundation|
|Collaborators ICMJE||Bausch & Lomb Incorporated|
|PRS Account||Lifelong Vision Foundation|
|Verification Date||February 2018|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP