Gycabiane and Glycemic Control of Prediabetic Subjects

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01530685
Recruitment Status : Unknown
Verified February 2012 by Pileje.
Recruitment status was:  Recruiting
First Posted : February 10, 2012
Last Update Posted : February 10, 2012
Information provided by (Responsible Party):

December 5, 2011
February 10, 2012
February 10, 2012
November 2011
April 2012   (Final data collection date for primary outcome measure)
Fast Blood Glucose [ Time Frame: 4 months ]
Fast blood glucose will be measured before and after 4 months of supplementation and after 2 months of wash-out
Same as current
No Changes Posted
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Gycabiane and Glycemic Control of Prediabetic Subjects
Effect of Glycabiane, a Dietary Supplement, on Glycemic Control of Prediabetic Subjects
The purpose of this study is to examine the effects of supplementation Glycabiane, a dietary supplement, on glycemic control of overweight prediabetic subjects.

Cinnamon's effects on blood glucose have been the subject of many clinical and animal studies; however, the issue of cinnamon intake's effect on fasting blood glucose (FBG) in people with prediabetes still remains unclear.

The main purpose of this study is to examine the effects of supplementation with Glycabiane, a dietary supplement rich in cinnamon extract, on fast blood glucose of overweight prediabetic subjects in a randomized, placebo-controlled, clinical trial.

Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
  • Dietary Supplement: Glycabiane
    2 gelule per day for 4 months
    Other Name: Dietary supplement
  • Dietary Supplement: placebo
    2 gelules per day for 4 months
  • Experimental: Glycabiane, gelule
    Intervention: Dietary Supplement: Glycabiane
  • Placebo Comparator: Placebo
    Intervention: Dietary Supplement: placebo
Liu Y, Cotillard A, Vatier C, Bastard JP, Fellahi S, Stévant M, Allatif O, Langlois C, Bieuvelet S, Brochot A, Guilbot A, Clément K, Rizkalla SW. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One. 2015 Sep 25;10(9):e0138646. doi: 10.1371/journal.pone.0138646. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0145315.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
Same as current
August 2012
April 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male or female from 25 to 65 years old
  • 1.0g/L ≤ fast blood glucose < 1.26g/L
  • overweight (IMC > 25)

Exclusion Criteria:

  • thyroid disease
  • hypogonadism
  • History of musculoskeletal, autoimmune or neurological disease
  • Treatment against thyroid disease, hypoglycemia, hypertension, or anti-coagulant
  • Pregnant or lactating women
Sexes Eligible for Study: All
25 Years to 65 Years   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
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Principal Investigator: Karine Clément, MD INSERM U872
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP