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Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01528956
Recruitment Status : Completed
First Posted : February 8, 2012
Last Update Posted : May 18, 2016
Information provided by (Responsible Party):

February 5, 2012
February 8, 2012
May 18, 2016
February 2012
May 2016   (Final data collection date for primary outcome measure)
  • Identification of genetic factors affecting adrenocortical tumors
  • Comprehensive catalog of altered genes in adrenocortical samples
Same as current
Complete list of historical versions of study NCT01528956 on ClinicalTrials.gov Archive Site
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Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.


  • To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.

OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Observational Model: Case-Only
Time Perspective: Retrospective
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Non-Probability Sample
Patients enrolled on COG-ARAR0332
Adrenocortical Carcinoma
  • Genetic: DNA methylation analysis
  • Genetic: RNA analysis
  • Genetic: gene expression analysis
  • Genetic: nucleic acid sequencing
  • Genetic: polymorphism analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
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May 2016   (Final data collection date for primary outcome measure)


  • Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil


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Sexes Eligible for Study: All
up to 21 Years   (Child, Adult)
Contact information is only displayed when the study is recruiting subjects
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COG-ARAR12B1 ( Other Identifier: Children's Oncology Group )
CDR0000724572 ( Other Identifier: Clinical trials.gov )
ARAR12B1 ( Other Identifier: Children's Oncology Group )
NCI-2012-00244 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
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Children's Oncology Group
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Gerard Zambetti, PhD St. Jude Children's Research Hospital
Children's Oncology Group
May 2016