Natural History of Carotid Atherosclerosis

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2015 by University of Athens
Sponsor:
Information provided by (Responsible Party):
Konstantinos Toutouzas, University of Athens
ClinicalTrials.gov Identifier:
NCT01521351
First received: January 25, 2012
Last updated: May 26, 2015
Last verified: May 2015

January 25, 2012
May 26, 2015
January 2012
December 2016   (final data collection date for primary outcome measure)
To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Microwave radiometry is a non invasive and safe technique that measures temperature of the internal tissues by detecting the normal radiation of the tissues in microwave frequencies. The primary outcome of the study is to see if the temperatures measured in the carotid arteries of patients with coronary artery disease can predict their outcome regarding cerebrovascular and cardiovascular events
Same as current
Complete list of historical versions of study NCT01521351 on ClinicalTrials.gov Archive Site
Relation of other demographic factors with carotid ultrasound and microwave radiometry measurements and outcome [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Natural History of Carotid Atherosclerosis
A Prospective Natural History Study of Carotid Atherosclerosis
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded
Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample
Patients with coronary artery disease
  • Carotid Artery Disease
  • Stroke
  • Myocardial Infarction
  • Angina Pectoris
Not Provided
  • carotid thermal heterogeneity
    Patients that have carotid thermal heterogeneity detected by MR
  • no carotid thermal heterogeneity
    Patients that DONT have carotid thermal heterogeneity detected by MR
  • carotid artery disease
    Patients with detected carotid artery disease by ultrasound
  • no carotid artery disease
    Patients with no carotid artery disease detected by ultrasound

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
700
December 2017
December 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Consecutive patients with coronary artery disease admitted in our hospital

Exclusion Criteria:

  • Patients with history of previous cerebrovascular event,
  • History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.
Both
30 Years to 80 Years   (Adult, Senior)
No
Contact: Konstantinos Toutouzas ktoutouz@gmail.com
Contact: Andreas Synetos synetos@yahoo.com
Greece
 
NCT01521351
MRcar
No
Not Provided
Not Provided
Konstantinos Toutouzas, University of Athens
University of Athens
Not Provided
Principal Investigator: Konstantinos Toutouzas First department of Cardiology, University of Athens Greece
University of Athens
May 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP