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Cognitive Training for Patients With Schizophrenia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01521026
First Posted: January 30, 2012
Last Update Posted: December 11, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Alliance for Research on Schizophrenia and Depression
Information provided by (Responsible Party):
ETwamley, University of California, San Diego
January 22, 2012
January 30, 2012
July 1, 2013
December 11, 2013
December 11, 2013
September 2003
August 2009   (Final data collection date for primary outcome measure)
UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) [ Time Frame: 3 months ]
Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores Scale ranges from 0-100. Subscales are summed to yield the total score. Higher scores represent better performance.
UCSD Performance-based Skills Assessment Total Score [ Time Frame: 3 months ]
Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores
Complete list of historical versions of study NCT01521026 on ClinicalTrials.gov Archive Site
Hopkins Verbal Learning Test Percent Retained [ Time Frame: 3 months ]

Verbal list learning task with three learning trials and a delay trial. Percent retained refers to the percentage of items recalled at the delay trial, compared to the third learning trial.

Score ranges from 0-100. Higher scores represent better performance.

Cognitive performance [ Time Frame: 0, 3, 6 months ]
Not Provided
Not Provided
 
Cognitive Training for Patients With Schizophrenia
Cognitive Training for Patients With Schizophrenia

This research on cognitive training addresses the following questions:

  1. Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses?
  2. What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).
Not Provided
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
  • Schizophrenia
  • Schizoaffective Disorder
  • Other Primary Psychotic Disorders
Behavioral: Cognitive Training
12-week compensatory cognitive training in group format
  • Experimental: Cognitive Training
    Cognitive training group
    Intervention: Behavioral: Cognitive Training
  • No Intervention: Standard Pharmacotherapy
Twamley EW, Vella L, Burton CZ, Heaton RK, Jeste DV. Compensatory cognitive training for psychosis: effects in a randomized controlled trial. J Clin Psychiatry. 2012 Sep;73(9):1212-9. doi: 10.4088/JCP.12m07686. Epub 2012 Aug 7.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
69
August 2009
August 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS)
  • Age 18 or older
  • Fluency in English

Exclusion Criteria:

  • Dementia
  • Neurological conditions affecting cognition
  • Mental retardation
  • Substance use disorder within the past month
  • Participation in other intervention trials
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01521026
NARSAD Young Investigator
Yes
Not Provided
Not Provided
ETwamley, University of California, San Diego
University of California, San Diego
National Alliance for Research on Schizophrenia and Depression
Principal Investigator: Elizabeth W Twamley, PhD UCSD
University of California, San Diego
November 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP