Duration of Leg Nerve Blocks With Dexamethasone Added to Local Anesthetic
|ClinicalTrials.gov Identifier: NCT01511211|
Recruitment Status : Withdrawn (Other researchers have published results on a similar trial)
First Posted : January 18, 2012
Last Update Posted : September 12, 2013
|First Submitted Date ICMJE||January 12, 2012|
|First Posted Date ICMJE||January 18, 2012|
|Last Update Posted Date||September 12, 2013|
|Study Start Date ICMJE||September 2012|
|Actual Primary Completion Date||August 2013 (Final data collection date for primary outcome measure)|
|Current Primary Outcome Measures ICMJE
||Duration of Analgesia [ Time Frame: 72 hours or first report of pain in the knee which ever is earliest ]
Duration of analgesia defined as the time interval between the end of local anesthetic injection and the patient's first report of pain in the knee.
|Original Primary Outcome Measures ICMJE||Same as current|
|Change History||Complete list of historical versions of study NCT01511211 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE||Same as current|
|Current Other Outcome Measures ICMJE||Not Provided|
|Original Other Outcome Measures ICMJE||Not Provided|
|Brief Title ICMJE||Duration of Leg Nerve Blocks With Dexamethasone Added to Local Anesthetic|
|Official Title ICMJE||Effect of Dexamethasone on Duration of Analgesia After Ultrasound-Guided Femoral, Obturator, and Popliteal Blocks With Ropivacaine in Total Knee Arthroplasty|
|Brief Summary||This is a Randomized Double blinded controlled trial on the effect of adding dexamethasone to Ropivacaine on the duration of pain relief for ultrasound guided femoral, obturator and popliteal block after total knee replacement surgery.|
This is a double blinded randomized controlled trial on the effect on duration of action when we add dexamethasone to our 3 routine peripheral nerve blocks (femoral, obturator and sciatic nerve) for total knee replacement surgery.
A computer generated randomization will determine if dexamethasone 8mg (2 cc of 4mg/cc) will be given to the patient intravenously or mixed with the ropivacaine for the lower limb blocks. A sham 2 ml of normal saline will be given in the other route. For example, if the patient is assigned to the Ropivacaine + Dexamethasone Combination arm, 2 ml of dexamethasone will be drawn up and labeled "PNB" (peripheral nerve block) by a person not involved in the block or anesthetic management of the patient and given to the regional anesthesiologist to add to their local anesthetic solution. Another 2 ml of normal saline labeled (IV) will be drawn up by the same person and the sham will be given to the anesthesia team taking care of the patient during surgery for them to give it to the patient intravenously just before the start of the surgery.
Alternatively, if the patient is assigned to the Ropivacaine-Only Block arm, a person not involved in the patient care will draw up 2 ml of normal saline and label it "PNB" and give it to the regional anesthesiologist and 2ml of dexamethasone and label it "IV" to the anesthesia team taking care of the patient during surgery for them to give it to the patient intravenously just before the start of surgery.
70 patients will be randomly selected to receive either:
A sealed envelope will be given to an anesthesia provider not involved in the peripheral nerve block, follow up assessment of the block or provide perioperative anesthesia care to the patient. This person would draw up 2 cc of dexamethasone and 2 cc of normal saline and label them for intravenous (IV) injection or addition to the ropivacaine mixture in the lower limb block (PNB) depending on the instructions in the envelope.
The anesthesia provider performing the peripheral nerve block, providing perioperative anesthesia care including the general anesthesia or monitored anesthesia care nor the anesthesia providers assessing the patients block will not have information regarding the route of dexamethasone given.
All blocks are to be performed by 1 of our 7 regional anesthesiologists with expertise in ultrasound-guided lower limb blocks who will be blinded to the presence of dexamethasone to the local anesthetic. Blinding the performer will help to eliminate performance bias. Two 20 cc syringes of 0.5% ropivacaine will be prepared for the block. One cc of the study drug will be injected into each syringe and mixed.
Before nerve blockade, all patients will receive intravenous access and standard monitoring, which included noninvasive blood pressure, electrocardiogram, and pulse oximetry.
Sedation and anxiolysis are achieved with intravenously administered midazolam in 1- to 2-mg increments up to 5 mg and fentanyl in 25 ug increments as needed up to 250 ug.
POPLITEAL NERVE BLOCK
Popliteal nerve block will be performed with the patient lying supine and the operative leg propped up on an elevation pillow allowing the posterior popliteal fossa to be accessed. A linear, high-frequency US probe of 5 to 12 MHz (S-nerve, sonosite) covered with a sterile dressing will be placed in the popliteal fossa in a transverse plane. The tibial and common peroneal nerve are identified superficial and lateral to the popliteal vessels then traced cephalad until they unite. This is the point of needle placement.
After sterilization and application of LA (3ml of 0.5% lidocaine) to the skin, a 22-gauge, Tuohy is advanced through the skin at the lateral border thigh in alignment with the long axis of the ultrasound probe in the same plane as the US beam (ie, in-plane technique). The needle is to be positioned under US guidance to the tibial nerve and common peroneal nerve.
The needle is to be always visualized before LA injection. Hydrolocation or dissection beyond 3 cc is not to be used to avoid dilution effect. Once needle position was satisfactory and after negative aspiration, 10 mL of LA is to be injected incrementally over 2 minutes with direct sonographic visualization of the LA spread around the tibial nerve. The needle is to be repositioned under US guidance to ensure adequate spread of LA around the tibial nerve. A circumferential spread of the LA is sought. Extra care is taken never to inject within the nerve. Expansion and compartmentalization of the nerve structure will result in abandonment of the study. Similarly, 10 ml of LA is injected circumferentially around the common peroneal nerve.
FEMORAL NERVE BLOCK
OBTURATOR NERVE BLOCK The single shot obturator nerve block is performed with the patient lying supine with the leg slightly abducted and flexed at the hip joint. The same ultrasound probe is used and positioned more medially to locate the fascial plane between the adductor brevis and adductor magnus where the posterior division of the obturator nerve lies. After local infiltration of the skin with 3cc of 1% lidocaine, a 22 G Tuohy needle is advanced in plane with until it lies within the fascial plane of the adductor magnus and adductor brevis. No more than 3 cc of hydrolocation or hydrodissection is allowed. 5 cc of ropivacaine is injected here taking care that hydrodissection of the fascial plane occurs and avoiding intramuscular injection.
INTRAOP General anesthesia is performed in the usual fashion. Fentanyl is used intraoperatively if the heart rate or blood pressure deviated greater than 20% from the baseline if deemed appropriate. No other opioid or analgesics (such as ketorolac or ketamine) will be given as per institutional practice. If there is suspicion that the blocks are not working intraoperatively, the patient may be withdrawn from the study and alternative analgesia may be given. The dexamethasone or sham is given at the beginning of the surgery and ondansetron 4 mg is given at the end of surgery.
POST-ANESTHESIA CARE UNIT In PACU, the patient is evaluated for femoral, sciatic and obturator block success. If any of the 3 blocks are deemed non functional, the patient is withdrawn from the study and noted.
The patient will be given hydromorphone 0.2mg IV boluses in PACU to maintain the VAS score below 4 if necessary. The standard institutional hydromorphone PCA set at 0.2mg bolus every 10 minutes with no basal.
At the time of discharge from PACU, the patients are given a diary to record their perception of sensation and movement every awake hour on a scale of 0 to 2. Zero being no sensation, 1 = some sensation and 2 being full sensation being recorded separately on top of the foot and on the bottom of the foot. Similarly a 0 to 2 scale for strength. 0 being no movement, 1= some movement, 2 = full strength in pointing the toes towards the nose and in pointing the toes away from the nose.
Patients will also be given instructions to record the location of their pain when it first returns and each time they require pain medications; being on top or at the bottom of the knee.
FOLLOW UP All patients will be be seen the day after the surgery for their time to first return of sensation and time to first return of movement. Also information regarding the full return of sensation and time to full return of movement is obtained. If sensory and motor function remains intact, a further interview will be conducted daily until full sensory and motor function returns. All complications will be noted.
All patients will have their PCA and medication records checked for the time of their first request for analgesia. Patients will be interviewed on the location of their pain for this request for analgesia if the patient's pain location record is ambiguous.
|Study Type ICMJE||Interventional|
|Study Phase||Phase 4|
|Study Design ICMJE||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Publications *||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Withdrawn|
|Actual Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Actual Study Completion Date||August 2013|
|Actual Primary Completion Date||August 2013 (Final data collection date for primary outcome measure)|
|Eligibility Criteria ICMJE||
|Ages||18 Years and older (Adult, Senior)|
|Accepts Healthy Volunteers||No|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries ICMJE||United States|
|Removed Location Countries|
|NCT Number ICMJE||NCT01511211|
|Other Study ID Numbers ICMJE||UNMLAMLLDEX|
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Nicholas Lam, University of New Mexico|
|Study Sponsor ICMJE||University of New Mexico|
|Collaborators ICMJE||Not Provided|
|PRS Account||University of New Mexico|
|Verification Date||September 2013|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP