Service Member Fatigue and Lack of Motivation Following Concussion

Tracking Information
First Submitted Date	December 17, 2011
First Posted Date	December 21, 2011
Last Update Posted Date	April 20, 2018
Study Start Date	December 1, 2011
Primary Completion Date	Not Provided
Current Primary Outcome Measures; (submitted: August 20, 2014)	Correlations between fractional anisotropy, effective connectivity measured by size of cortical and subcortical structures on DTI, and VBM that correlate with measures of fatigue, apathy, effort expenditure. [ Time Frame: One year ]
Original Primary Outcome Measures	Not Provided
Change History	Complete list of historical versions of study NCT01496586 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures; (submitted: August 20, 2014)	Correlations between fractional anisotropy, effective connectivity measured by size of cortical and subcortical structures on DTI, and VBM that correlate with measures of alexithymia and perceived stress [ Time Frame: One year ]
Original Secondary Outcome Measures	Not Provided
Current Other Outcome Measures	Not Provided
Original Other Outcome Measures	Not Provided
Descriptive Information
Brief Title	Service Member Fatigue and Lack of Motivation Following Concussion
Official Title	Fatigue and Amotivation Following Mild Traumatic Brain Injury and Their Influence on Service Member Community Reintegration
Brief Summary	Background: - Many service members have reported feeling tired, a loss of motivation, mood changes, and problems working with others after they have a concussion during deployment. These problems may lead to problems with their job and relationships. This study hopes to figure out what parts of the brain may be affected in people with these problems after a concussion. Objectives: - To learn more about the problems that may occur after service members have a concussion during deployment and return home. Eligibility: Service members or veterans between 18 and 40 years of age who have had a mild traumatic brain injury (concussion) in the past 6 months.; Companions (at least 18 years of age) of the service members will also be included in this study. Companions will have interacted with the service member at least 1 hour a week since deployment. Design: Service members will have 1 week of tests at the National Institutes of Health Clinical Center. Companions will have 2 days of tests at the Center.; Each day, service members will have 4 or 8 hours of tests. Tests will include a medical history and physical exam, neuropsychological tests and imaging studies. The tests will ask about fatigue, stress, mood, pain, daily activities, and family support. The imaging studies will measure brain function at rest and during activity.; Companions will have a medical history and physical exam. They will also complete several questionnaires about themselves as well as the service member/veteran. The tests will ask about fatigue, stress, mood, pain, daily activities, and family support.
Detailed Description	Objective: The primary objective of this study is to determine the behavioral-anatomical relationships that underlie fatigue and amotivation following mild traumatic brain injury in deployed military service members. The specific aims are to 1) determine the neural correlates of fatigue, and 2) assess how fatigue and social cognition relate to social outcomes including employment, community integration and participation in social activities. The theory we will test is that fatigue in this population is the result of subtle changes in frontal cortical and subcortical structures. Study Design: Observational, natural history study. Populations: 1) Individuals who have sustained a mild traumatic brain injury as a service member deployed in support of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn, and who continue to experience symptoms more than 6 months after injury, and 2) Companions of individuals from the first group. Outcome Measures: We will seek statistical associations between fatigue measures and brain morphometric and white matter diffusion measurements obtained by MRI as well as task and resting state fMRI.
Study Type	Observational
Study Design	Observational Model: Cohort; Time Perspective: Cross-Sectional
Target Follow-Up Duration	Not Provided
Biospecimen	Not Provided
Sampling Method	Not Provided
Study Population	Not Provided
Condition	Fatigue; Traumatic Brain Injury
Intervention	Not Provided
Study Groups/Cohorts	Not Provided
Publications *	Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008 Jan 31;358(5):453-63. doi: 10.1056/NEJMoa072972. Epub 2008 Jan 30.; Jones E, Fear NT, Wessely S. Shell shock and mild traumatic brain injury: a historical review. Am J Psychiatry. 2007 Nov;164(11):1641-5.; Jones E, Hodgins-Vermaas R, McCartney H, Everitt B, Beech C, Poynter D, Palmer I, Hyams K, Wessely S. Post-combat syndromes from the Boer war to the Gulf war: a cluster analysis of their nature and attribution. BMJ. 2002 Feb 9;324(7333):321-4. Erratum in: BMJ 2002 Feb 16;324(7334):397.
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Recruitment Information
Recruitment Status	Completed
Actual Enrollment; (submitted: August 4, 2015)	45
Original Estimated Enrollment; (submitted: December 17, 2011)	160
Study Completion Date	August 3, 2015
Primary Completion Date	Not Provided
Eligibility Criteria	INCLUSION CRITERIA mTBI GROUP:; Diagnosis of at least one mTBI during deployment;; At least six months from time of injury;; Age range 18 or older;; A self-report of somatic or behavioral symptoms that developed within 3 months following mTBI and were not present before injury, and may or may not be present at enrollment: Easy fatiguability Sleep disturbance Headache or other chronic widespread pain that does not seem related to extremity injury Emotional lability Lack of spontaneity or apathy Lack of motivation Feelings of anxiety Personality change that they or others have noticed Irritability or aggressiveness; The mTBI participant provides informed consent. EXCLUSION CRITERIA mTBI GROUP: Daily use of stimulants, narcotics, hypnotic or anxiolytics; Diagnosis of sleep apnea, thyroid disorder, or rheumatoid arthritis; Any history of head injury associated with a loss of consciousness that lasted longer than 24 hours (not including sedation);; Daily use of more than 600mg caffeine (equivalent to approximately five cups of coffee).; Headaches more than once a month prior to deployment;; Pregnancy;; Claustrophia;; Inability to comfortably lie supine for two hours INCLUSION CRITERIA companion group; Chosen by a mTBI participant as a close companion (i.e, spends or in the last 3 years has spent a minimum of 1 hour per week on average with the mTBI participant and with whom the mTBI participant is comfortable discussing personal matters);; The companion provides informed consent. EXCLUSION CRITERIA companion group: -Lack of understanding of the English language
Sex/Gender	Sexes Eligible for Study: All
Ages	18 Years and older (Adult, Senior)
Accepts Healthy Volunteers	No
Contacts	Contact information is only displayed when the study is recruiting subjects
Listed Location Countries	United States
Removed Location Countries
Administrative Information
NCT Number	NCT01496586
Other Study ID Numbers	120030; 12-N-0030
Has Data Monitoring Committee	Not Provided
U.S. FDA-regulated Product	Not Provided
IPD Sharing Statement	Not Provided
Responsible Party	National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )
Study Sponsor	National Institute of Neurological Disorders and Stroke (NINDS)
Collaborators	Not Provided
Investigators	Principal Investigator: Eric M Wassermann, M.D. National Institute of Neurological Disorders and Stroke (NINDS)
PRS Account	National Institutes of Health Clinical Center (CC)
Verification Date	August 3, 2015