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Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01493128
First received: December 13, 2011
Last updated: March 10, 2017
Last verified: March 2017

December 13, 2011
March 10, 2017
April 2010
February 2012   (Final data collection date for primary outcome measure)
structure of sarcolemma [ Time Frame: 1 hour ]
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Complete list of historical versions of study NCT01493128 on ClinicalTrials.gov Archive Site
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Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation

The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since current information is lacking on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF), it will be investigated whether a regulation of these proteins could be an underlying cause of the disease. Mitochondrial function will also studied.

  1. The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
  2. The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.
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Observational
Observational Model: Case-Control
Time Perspective: Cross-Sectional
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Retention:   Samples Without DNA
Description:
Myocardial tissue from the right and left atrial appendage.
Non-Probability Sample
selected for open heart surgery in St Olavs Hospital, Trondheim University Hospital, Norway
Atrial Fibrillation
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  • stable sinus rhythm
  • permanent atrial fibrillation
  • paroxysmal atrial fibrillation
Slagsvold KH, Johnsen AB, Rognmo O, Høydal MA, Wisløff U, Wahba A. Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. Physiol Genomics. 2014 Jul 15;46(14):505-11. doi: 10.1152/physiolgenomics.00042.2014.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
45
July 2012
February 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • sinus rhythm, permanent atrial fibrillation or paroxysmal atrial fibrillation
  • selected for open heart surgery
  • informed consent

Exclusion Criteria:

  • not given informed consent
Sexes Eligible for Study: All
50 Years to 85 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
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NCT01493128
ABJ01
No
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
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Norwegian University of Science and Technology
Norwegian University of Science and Technology
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Study Director: Ulrik Wisløff, PhD Norwegian University of Science and Technology
Norwegian University of Science and Technology
March 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP